node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
1810009J06Rik | Ctrb1 | ENSMUSP00000075935 | ENSMUSP00000034435 | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | Chymotrypsin B chain A; Belongs to the peptidase S1 family. | 0.631 |
1810009J06Rik | F2r | ENSMUSP00000075935 | ENSMUSP00000061754 | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. | 0.731 |
1810009J06Rik | F2rl1 | ENSMUSP00000075935 | ENSMUSP00000022185 | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | Proteinase-activated receptor 2; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF- kappaB and Rho. Can also be transactivated by cleaved F2r/Par1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistical [...] | 0.801 |
1810009J06Rik | F2rl2 | ENSMUSP00000075935 | ENSMUSP00000022182 | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | Proteinase-activated receptor 3; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | 0.655 |
1810009J06Rik | F2rl3 | ENSMUSP00000075935 | ENSMUSP00000054426 | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | Proteinase-activated receptor 4; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | 0.650 |
1810009J06Rik | Gm2663 | ENSMUSP00000075935 | ENSMUSP00000130465 | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | Predicted gene 2663; Belongs to the peptidase S1 family. | 0.813 |
1810009J06Rik | Ins1 | ENSMUSP00000075935 | ENSMUSP00000049095 | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | Insulin-1 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.599 |
1810009J06Rik | Ins2 | ENSMUSP00000075935 | ENSMUSP00000147425 | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | Insulin-2 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.603 |
1810009J06Rik | Pard3 | ENSMUSP00000075935 | ENSMUSP00000125453 | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | Partitioning defective 3 homolog; Adapter protein involved in asymmetrical cell division and cell polarization processes (By similarity). Seems to play a central role in the formation of epithelial tight junctions (By similarity). Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Required for establishment of neuronal polarity and normal axon [...] | 0.650 |
1810009J06Rik | Spink1 | ENSMUSP00000075935 | ENSMUSP00000025381 | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens. | 0.696 |
Ctrb1 | 1810009J06Rik | ENSMUSP00000034435 | ENSMUSP00000075935 | Chymotrypsin B chain A; Belongs to the peptidase S1 family. | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | 0.631 |
Ctrb1 | Gm2663 | ENSMUSP00000034435 | ENSMUSP00000130465 | Chymotrypsin B chain A; Belongs to the peptidase S1 family. | Predicted gene 2663; Belongs to the peptidase S1 family. | 0.500 |
Ctrb1 | Ins1 | ENSMUSP00000034435 | ENSMUSP00000049095 | Chymotrypsin B chain A; Belongs to the peptidase S1 family. | Insulin-1 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.614 |
Ctrb1 | Ins2 | ENSMUSP00000034435 | ENSMUSP00000147425 | Chymotrypsin B chain A; Belongs to the peptidase S1 family. | Insulin-2 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.677 |
Ctrb1 | Spink1 | ENSMUSP00000034435 | ENSMUSP00000025381 | Chymotrypsin B chain A; Belongs to the peptidase S1 family. | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens. | 0.563 |
F2r | 1810009J06Rik | ENSMUSP00000061754 | ENSMUSP00000075935 | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | 0.731 |
F2r | F2rl1 | ENSMUSP00000061754 | ENSMUSP00000022185 | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. | Proteinase-activated receptor 2; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF- kappaB and Rho. Can also be transactivated by cleaved F2r/Par1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistical [...] | 0.467 |
F2r | F2rl2 | ENSMUSP00000061754 | ENSMUSP00000022182 | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. | Proteinase-activated receptor 3; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | 0.506 |
F2r | F2rl3 | ENSMUSP00000061754 | ENSMUSP00000054426 | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. | Proteinase-activated receptor 4; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | 0.913 |
F2r | Gm2663 | ENSMUSP00000061754 | ENSMUSP00000130465 | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. | Predicted gene 2663; Belongs to the peptidase S1 family. | 0.730 |