node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bud13 | Cwc22 | ENSMUSP00000074490 | ENSMUSP00000064947 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | 0.936 |
Bud13 | Cwc27 | ENSMUSP00000074490 | ENSMUSP00000022228 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | 0.984 |
Bud13 | Dhx16 | ENSMUSP00000074490 | ENSMUSP00000025292 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | DEAH (Asp-Glu-Ala-His) box polypeptide 16. | 0.987 |
Bud13 | Dhx38 | ENSMUSP00000074490 | ENSMUSP00000047865 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | DEAH (Asp-Glu-Ala-His) box polypeptide 38. | 0.876 |
Bud13 | Gpkow | ENSMUSP00000074490 | ENSMUSP00000076178 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | G-patch domain and KOW motifs-containing protein; RNA-binding protein involved in pre-mRNA splicing. Belongs to the MOS2 family. | 0.926 |
Bud13 | Ppil2 | ENSMUSP00000074490 | ENSMUSP00000155861 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | RING-type E3 ubiquitin-protein ligase PPIL2; Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'- linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | 0.578 |
Bud13 | Prpf8 | ENSMUSP00000074490 | ENSMUSP00000018449 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | Pre-mRNA-processing-splicing factor 8; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both t [...] | 0.982 |
Bud13 | Rnf113a1 | ENSMUSP00000074490 | ENSMUSP00000042569 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | Ring finger protein 113A1. | 0.958 |
Cwc22 | Bud13 | ENSMUSP00000064947 | ENSMUSP00000074490 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | 0.936 |
Cwc22 | Cwc27 | ENSMUSP00000064947 | ENSMUSP00000022228 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | 0.975 |
Cwc22 | Dhx16 | ENSMUSP00000064947 | ENSMUSP00000025292 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | DEAH (Asp-Glu-Ala-His) box polypeptide 16. | 0.920 |
Cwc22 | Dhx38 | ENSMUSP00000064947 | ENSMUSP00000047865 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | DEAH (Asp-Glu-Ala-His) box polypeptide 38. | 0.951 |
Cwc22 | Gpkow | ENSMUSP00000064947 | ENSMUSP00000076178 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | G-patch domain and KOW motifs-containing protein; RNA-binding protein involved in pre-mRNA splicing. Belongs to the MOS2 family. | 0.866 |
Cwc22 | Ppil2 | ENSMUSP00000064947 | ENSMUSP00000155861 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | RING-type E3 ubiquitin-protein ligase PPIL2; Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'- linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | 0.857 |
Cwc22 | Prpf8 | ENSMUSP00000064947 | ENSMUSP00000018449 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | Pre-mRNA-processing-splicing factor 8; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both t [...] | 0.937 |
Cwc22 | Rnf113a1 | ENSMUSP00000064947 | ENSMUSP00000042569 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | Ring finger protein 113A1. | 0.914 |
Cwc22 | Srrt | ENSMUSP00000064947 | ENSMUSP00000043123 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. [...] | 0.826 |
Cwc27 | Bud13 | ENSMUSP00000022228 | ENSMUSP00000074490 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | 0.984 |
Cwc27 | Cwc22 | ENSMUSP00000022228 | ENSMUSP00000064947 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family. | 0.975 |
Cwc27 | Dhx16 | ENSMUSP00000022228 | ENSMUSP00000025292 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | DEAH (Asp-Glu-Ala-His) box polypeptide 16. | 0.987 |