node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abca1 | Zdhhc8 | ENSMUSP00000030010 | ENSMUSP00000076224 | Phospholipid-transporting ATPase ABCA1; Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates to phospholipids transfer to apoliproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apoliproteins and the formation of nascent high density lipoproteins/HDLs; Belongs to the ABC transporter superfamily. ABCA family. | Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. | 0.753 |
Comt | Dgcr2 | ENSMUSP00000130077 | ENSMUSP00000012152 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | 0.562 |
Comt | Gnb1l | ENSMUSP00000130077 | ENSMUSP00000087544 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Guanine nucleotide-binding protein subunit beta-like protein 1. | 0.638 |
Comt | Mrpl40 | ENSMUSP00000130077 | ENSMUSP00000023391 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 39S ribosomal protein L40, mitochondrial. | 0.474 |
Comt | Prodh | ENSMUSP00000130077 | ENSMUSP00000003620 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.841 |
Comt | Tango2 | ENSMUSP00000130077 | ENSMUSP00000111291 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Transport and Golgi organization 2 homolog. | 0.441 |
Comt | Trmt2a | ENSMUSP00000130077 | ENSMUSP00000111304 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | tRNA (uracil-5-)-methyltransferase homolog A. | 0.478 |
Comt | Zdhhc8 | ENSMUSP00000130077 | ENSMUSP00000076224 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. | 0.772 |
Dgcr2 | Comt | ENSMUSP00000012152 | ENSMUSP00000130077 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.562 |
Dgcr2 | Gnb1l | ENSMUSP00000012152 | ENSMUSP00000087544 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | Guanine nucleotide-binding protein subunit beta-like protein 1. | 0.639 |
Dgcr2 | Mrpl40 | ENSMUSP00000012152 | ENSMUSP00000023391 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | 39S ribosomal protein L40, mitochondrial. | 0.628 |
Dgcr2 | Prodh | ENSMUSP00000012152 | ENSMUSP00000003620 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.787 |
Dgcr2 | Tango2 | ENSMUSP00000012152 | ENSMUSP00000111291 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | Transport and Golgi organization 2 homolog. | 0.538 |
Dgcr2 | Trmt2a | ENSMUSP00000012152 | ENSMUSP00000111304 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | tRNA (uracil-5-)-methyltransferase homolog A. | 0.625 |
Dgcr2 | Zdhhc8 | ENSMUSP00000012152 | ENSMUSP00000076224 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. | 0.795 |
Gnb1l | Comt | ENSMUSP00000087544 | ENSMUSP00000130077 | Guanine nucleotide-binding protein subunit beta-like protein 1. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.638 |
Gnb1l | Dgcr2 | ENSMUSP00000087544 | ENSMUSP00000012152 | Guanine nucleotide-binding protein subunit beta-like protein 1. | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | 0.639 |
Gnb1l | Mrpl40 | ENSMUSP00000087544 | ENSMUSP00000023391 | Guanine nucleotide-binding protein subunit beta-like protein 1. | 39S ribosomal protein L40, mitochondrial. | 0.520 |
Gnb1l | Prodh | ENSMUSP00000087544 | ENSMUSP00000003620 | Guanine nucleotide-binding protein subunit beta-like protein 1. | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.701 |
Gnb1l | Tango2 | ENSMUSP00000087544 | ENSMUSP00000111291 | Guanine nucleotide-binding protein subunit beta-like protein 1. | Transport and Golgi organization 2 homolog. | 0.579 |