node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
4921524L21Rik | Cyp4f37 | ENSMUSP00000035514 | ENSMUSP00000076827 | RIKEN cDNA 4921524L21 gene. | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | 0.410 |
Cyp2b19 | Cyp2c55 | ENSMUSP00000077021 | ENSMUSP00000025966 | Cytochrome P450 2B19; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Cytochrome P450 2C55; Metabolizes arachidonic acid mainly to 19- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family. | 0.662 |
Cyp2b19 | Cyp4f37 | ENSMUSP00000077021 | ENSMUSP00000076827 | Cytochrome P450 2B19; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | 0.402 |
Cyp2c55 | Cyp2b19 | ENSMUSP00000025966 | ENSMUSP00000077021 | Cytochrome P450 2C55; Metabolizes arachidonic acid mainly to 19- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family. | Cytochrome P450 2B19; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.662 |
Cyp2c55 | Cyp4f37 | ENSMUSP00000025966 | ENSMUSP00000076827 | Cytochrome P450 2C55; Metabolizes arachidonic acid mainly to 19- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family. | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | 0.413 |
Cyp4f37 | 4921524L21Rik | ENSMUSP00000076827 | ENSMUSP00000035514 | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | RIKEN cDNA 4921524L21 gene. | 0.410 |
Cyp4f37 | Cyp2b19 | ENSMUSP00000076827 | ENSMUSP00000077021 | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | Cytochrome P450 2B19; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.402 |
Cyp4f37 | Cyp2c55 | ENSMUSP00000076827 | ENSMUSP00000025966 | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | Cytochrome P450 2C55; Metabolizes arachidonic acid mainly to 19- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family. | 0.413 |
Cyp4f37 | Mtrr | ENSMUSP00000076827 | ENSMUSP00000152387 | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | Methionine synthase reductase; Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects. | 0.492 |
Cyp4f37 | Ndor1 | ENSMUSP00000076827 | ENSMUSP00000109989 | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | 0.626 |
Cyp4f37 | Pagr1a | ENSMUSP00000076827 | ENSMUSP00000144469 | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | PAXIP1 associated glutamate rich protein 1A. | 0.431 |
Cyp4f37 | Por | ENSMUSP00000076827 | ENSMUSP00000005651 | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family. | 0.914 |
Cyp4f37 | Sqle | ENSMUSP00000076827 | ENSMUSP00000022977 | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. | 0.421 |
Mtrr | Cyp4f37 | ENSMUSP00000152387 | ENSMUSP00000076827 | Methionine synthase reductase; Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects. | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | 0.492 |
Ndor1 | Cyp4f37 | ENSMUSP00000109989 | ENSMUSP00000076827 | NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | 0.626 |
Pagr1a | Cyp4f37 | ENSMUSP00000144469 | ENSMUSP00000076827 | PAXIP1 associated glutamate rich protein 1A. | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | 0.431 |
Por | Cyp4f37 | ENSMUSP00000005651 | ENSMUSP00000076827 | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family. | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | 0.914 |
Por | Sqle | ENSMUSP00000005651 | ENSMUSP00000022977 | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family. | Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. | 0.464 |
Sqle | Cyp4f37 | ENSMUSP00000022977 | ENSMUSP00000076827 | Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. | Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family. | 0.421 |
Sqle | Por | ENSMUSP00000022977 | ENSMUSP00000005651 | Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family. | 0.464 |