node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atpsckmt | Igdcc4 | ENSMUSP00000039094 | ENSMUSP00000045387 | ATP synthase subunit C lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia. | Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family. | 0.572 |
Atpsckmt | Tulp4 | ENSMUSP00000039094 | ENSMUSP00000049248 | ATP synthase subunit C lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia. | Tubby-related protein 4; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the TUB family. | 0.604 |
Draxin | Igdcc4 | ENSMUSP00000030862 | ENSMUSP00000045387 | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. | Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family. | 0.583 |
Draxin | Ntn1 | ENSMUSP00000030862 | ENSMUSP00000104314 | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by [...] | 0.922 |
Draxin | Ntn3 | ENSMUSP00000030862 | ENSMUSP00000024931 | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. | Netrin-3; Netrins control guidance of CNS commissural axons and peripheral motor axons. | 0.619 |
Draxin | Ntn5 | ENSMUSP00000030862 | ENSMUSP00000103371 | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | 0.551 |
Igdcc4 | Atpsckmt | ENSMUSP00000045387 | ENSMUSP00000039094 | Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family. | ATP synthase subunit C lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia. | 0.572 |
Igdcc4 | Draxin | ENSMUSP00000045387 | ENSMUSP00000030862 | Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family. | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. | 0.583 |
Igdcc4 | Ntn1 | ENSMUSP00000045387 | ENSMUSP00000104314 | Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family. | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by [...] | 0.601 |
Igdcc4 | Ntn3 | ENSMUSP00000045387 | ENSMUSP00000024931 | Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family. | Netrin-3; Netrins control guidance of CNS commissural axons and peripheral motor axons. | 0.599 |
Igdcc4 | Ntn5 | ENSMUSP00000045387 | ENSMUSP00000103371 | Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family. | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | 0.599 |
Igdcc4 | Slc41a3 | ENSMUSP00000045387 | ENSMUSP00000037473 | Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family. | Solute carrier family 41 member 3; Belongs to the SLC41A transporter family. | 0.582 |
Igdcc4 | Timm17b | ENSMUSP00000045387 | ENSMUSP00000033498 | Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family. | Mitochondrial import inner membrane translocase subunit Tim17-B; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. | 0.581 |
Igdcc4 | Tmem8 | ENSMUSP00000045387 | ENSMUSP00000025010 | Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family. | Post-GPI attachment to proteins factor 6; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. Also indirectly involved in the tr [...] | 0.557 |
Igdcc4 | Trim9 | ENSMUSP00000045387 | ENSMUSP00000106151 | Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family. | E3 ubiquitin-protein ligase TRIM9; E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation; Belongs to the TRIM/RBCC family. | 0.563 |
Igdcc4 | Tulp4 | ENSMUSP00000045387 | ENSMUSP00000049248 | Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family. | Tubby-related protein 4; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the TUB family. | 0.572 |
Ntn1 | Draxin | ENSMUSP00000104314 | ENSMUSP00000030862 | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by [...] | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. | 0.922 |
Ntn1 | Igdcc4 | ENSMUSP00000104314 | ENSMUSP00000045387 | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by [...] | Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family. | 0.601 |
Ntn1 | Trim9 | ENSMUSP00000104314 | ENSMUSP00000106151 | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by [...] | E3 ubiquitin-protein ligase TRIM9; E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation; Belongs to the TRIM/RBCC family. | 0.594 |
Ntn3 | Draxin | ENSMUSP00000024931 | ENSMUSP00000030862 | Netrin-3; Netrins control guidance of CNS commissural axons and peripheral motor axons. | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. | 0.619 |