node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aar2 | Dyrk4 | ENSMUSP00000029158 | ENSMUSP00000077606 | Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Belongs to the AAR2 family. | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | 0.494 |
Chchd3 | Dyrk4 | ENSMUSP00000070149 | ENSMUSP00000077606 | MICOS complex subunit Mic19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | 0.418 |
Dcaf7 | Dyrk4 | ENSMUSP00000058168 | ENSMUSP00000077606 | DDB1- and CUL4-associated factor 7; Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | 0.766 |
Dyrk4 | Aar2 | ENSMUSP00000077606 | ENSMUSP00000029158 | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Belongs to the AAR2 family. | 0.494 |
Dyrk4 | Chchd3 | ENSMUSP00000077606 | ENSMUSP00000070149 | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | MICOS complex subunit Mic19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. | 0.418 |
Dyrk4 | Dcaf7 | ENSMUSP00000077606 | ENSMUSP00000058168 | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | DDB1- and CUL4-associated factor 7; Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). | 0.766 |
Dyrk4 | Nfkbil1 | ENSMUSP00000077606 | ENSMUSP00000035452 | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | NF-kappa-B inhibitor-like protein 1; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity). | 0.416 |
Dyrk4 | Phax | ENSMUSP00000077606 | ENSMUSP00000008445 | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | Phosphorylated adapter RNA export protein; A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric imp [...] | 0.641 |
Dyrk4 | Ripk2 | ENSMUSP00000077606 | ENSMUSP00000038833 | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequ [...] | 0.417 |
Dyrk4 | Rnh1 | ENSMUSP00000077606 | ENSMUSP00000147928 | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | Ribonuclease inhibitor; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis (By similarity). | 0.493 |
Dyrk4 | Slc13a5 | ENSMUSP00000077606 | ENSMUSP00000021161 | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | Solute carrier family 13 member 5; High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol (By similarity). Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. | 0.627 |
Dyrk4 | Trappc2l | ENSMUSP00000077606 | ENSMUSP00000015157 | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | Trafficking protein particle complex subunit 2-like protein; May play a role in vesicular transport from endoplasmic reticulum to Golgi. | 0.472 |
Nfkbil1 | Dyrk4 | ENSMUSP00000035452 | ENSMUSP00000077606 | NF-kappa-B inhibitor-like protein 1; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity). | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | 0.416 |
Nfkbil1 | Rnh1 | ENSMUSP00000035452 | ENSMUSP00000147928 | NF-kappa-B inhibitor-like protein 1; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity). | Ribonuclease inhibitor; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis (By similarity). | 0.435 |
Phax | Dyrk4 | ENSMUSP00000008445 | ENSMUSP00000077606 | Phosphorylated adapter RNA export protein; A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric imp [...] | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | 0.641 |
Ripk2 | Dyrk4 | ENSMUSP00000038833 | ENSMUSP00000077606 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequ [...] | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | 0.417 |
Rnh1 | Dyrk4 | ENSMUSP00000147928 | ENSMUSP00000077606 | Ribonuclease inhibitor; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis (By similarity). | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | 0.493 |
Rnh1 | Nfkbil1 | ENSMUSP00000147928 | ENSMUSP00000035452 | Ribonuclease inhibitor; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis (By similarity). | NF-kappa-B inhibitor-like protein 1; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity). | 0.435 |
Slc13a5 | Dyrk4 | ENSMUSP00000021161 | ENSMUSP00000077606 | Solute carrier family 13 member 5; High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol (By similarity). Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | 0.627 |
Trappc2l | Dyrk4 | ENSMUSP00000015157 | ENSMUSP00000077606 | Trafficking protein particle complex subunit 2-like protein; May play a role in vesicular transport from endoplasmic reticulum to Golgi. | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis. | 0.472 |