node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aff3 | Frmd3 | ENSMUSP00000092637 | ENSMUSP00000081514 | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | 0.445 |
Aff3 | Mctp2 | ENSMUSP00000092637 | ENSMUSP00000078302 | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | 0.452 |
Ano4 | Mctp2 | ENSMUSP00000138193 | ENSMUSP00000078302 | Anoctamin-4; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | 0.494 |
Fam174b | Mctp2 | ENSMUSP00000103080 | ENSMUSP00000078302 | Membrane protein FAM174B; Essential for Golgi structural integrity. Belongs to the FAM174 family. | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | 0.519 |
Fam174b | Rgma | ENSMUSP00000103080 | ENSMUSP00000091870 | Membrane protein FAM174B; Essential for Golgi structural integrity. Belongs to the FAM174 family. | Repulsive guidance molecule A; Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA- ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG- PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inacti [...] | 0.526 |
Frmd3 | Aff3 | ENSMUSP00000081514 | ENSMUSP00000092637 | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. | 0.445 |
Frmd3 | Mctp2 | ENSMUSP00000081514 | ENSMUSP00000078302 | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | 0.452 |
Hspb7 | Mctp2 | ENSMUSP00000099544 | ENSMUSP00000078302 | Heat shock protein beta-7. | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | 0.504 |
Hspb7 | Tmem182 | ENSMUSP00000099544 | ENSMUSP00000110413 | Heat shock protein beta-7. | Transmembrane protein 182. | 0.493 |
Mctp2 | Aff3 | ENSMUSP00000078302 | ENSMUSP00000092637 | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. | 0.452 |
Mctp2 | Ano4 | ENSMUSP00000078302 | ENSMUSP00000138193 | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | Anoctamin-4; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity. | 0.494 |
Mctp2 | Fam174b | ENSMUSP00000078302 | ENSMUSP00000103080 | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | Membrane protein FAM174B; Essential for Golgi structural integrity. Belongs to the FAM174 family. | 0.519 |
Mctp2 | Frmd3 | ENSMUSP00000078302 | ENSMUSP00000081514 | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. | 0.452 |
Mctp2 | Hspb7 | ENSMUSP00000078302 | ENSMUSP00000099544 | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | Heat shock protein beta-7. | 0.504 |
Mctp2 | Nub1 | ENSMUSP00000078302 | ENSMUSP00000143657 | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | NEDD8 ultimate buster 1; Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation (By similarity). | 0.507 |
Mctp2 | Rgma | ENSMUSP00000078302 | ENSMUSP00000091870 | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | Repulsive guidance molecule A; Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA- ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG- PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inacti [...] | 0.541 |
Mctp2 | Snrk | ENSMUSP00000078302 | ENSMUSP00000114132 | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | SNF-related serine/threonine-protein kinase; May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis (By similarity). | 0.482 |
Mctp2 | Snx14 | ENSMUSP00000078302 | ENSMUSP00000130116 | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | Sorting nexin-14; Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking. Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). Belongs to the sorting nexin family. | 0.455 |
Mctp2 | Tmem182 | ENSMUSP00000078302 | ENSMUSP00000110413 | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | Transmembrane protein 182. | 0.592 |
Nub1 | Mctp2 | ENSMUSP00000143657 | ENSMUSP00000078302 | NEDD8 ultimate buster 1; Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation (By similarity). | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family. | 0.507 |