node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adam19 | Adam1b | ENSMUSP00000011400 | ENSMUSP00000078343 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | Disintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation. | 0.479 |
Adam19 | Adam2 | ENSMUSP00000011400 | ENSMUSP00000022618 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | 0.476 |
Adam19 | Adam23 | ENSMUSP00000011400 | ENSMUSP00000084633 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity). | 0.508 |
Adam19 | Adam28 | ENSMUSP00000011400 | ENSMUSP00000022642 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | Disintegrin and metalloproteinase domain-containing protein 28; May play a role in organogenesis and organ-specific functions such as thymic T-cell development. | 0.528 |
Adam19 | Adam5 | ENSMUSP00000011400 | ENSMUSP00000052661 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | Disintegrin and metalloproteinase domain-containing protein 5; This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity). | 0.545 |
Adam19 | Adam7 | ENSMUSP00000011400 | ENSMUSP00000022640 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | Disintegrin and metalloproteinase domain-containing protein 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein. | 0.526 |
Adam1b | Adam19 | ENSMUSP00000078343 | ENSMUSP00000011400 | Disintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation. | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | 0.479 |
Adam1b | Adam2 | ENSMUSP00000078343 | ENSMUSP00000022618 | Disintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation. | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | 0.847 |
Adam1b | Adam23 | ENSMUSP00000078343 | ENSMUSP00000084633 | Disintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation. | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity). | 0.497 |
Adam1b | Adam28 | ENSMUSP00000078343 | ENSMUSP00000022642 | Disintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation. | Disintegrin and metalloproteinase domain-containing protein 28; May play a role in organogenesis and organ-specific functions such as thymic T-cell development. | 0.548 |
Adam1b | Adam5 | ENSMUSP00000078343 | ENSMUSP00000052661 | Disintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation. | Disintegrin and metalloproteinase domain-containing protein 5; This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity). | 0.527 |
Adam1b | Adam7 | ENSMUSP00000078343 | ENSMUSP00000022640 | Disintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation. | Disintegrin and metalloproteinase domain-containing protein 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein. | 0.525 |
Adam1b | Clgn | ENSMUSP00000078343 | ENSMUSP00000002259 | Disintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation. | Calmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions. Belongs to the calreticulin family. | 0.620 |
Adam1b | Izumo1 | ENSMUSP00000078343 | ENSMUSP00000033100 | Disintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation. | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. | 0.502 |
Adam1b | Pdilt | ENSMUSP00000078343 | ENSMUSP00000033267 | Disintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation. | Protein disulfide-isomerase-like protein of the testis; Probable redox-inactive chaperone involved in spermatogenesis. | 0.580 |
Adam1b | Zp3r | ENSMUSP00000078343 | ENSMUSP00000045443 | Disintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation. | Zona pellucida sperm-binding protein 3 receptor; Binds to ZP3 glycoprotein in egg zona pellucida. Probably involved in interactions between sperm acrosome and egg zona pellucida during and immediately following the acrosome reaction. | 0.480 |
Adam2 | Adam19 | ENSMUSP00000022618 | ENSMUSP00000011400 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | 0.476 |
Adam2 | Adam1b | ENSMUSP00000022618 | ENSMUSP00000078343 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Disintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation. | 0.847 |
Adam2 | Adam23 | ENSMUSP00000022618 | ENSMUSP00000084633 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity). | 0.491 |
Adam2 | Adam28 | ENSMUSP00000022618 | ENSMUSP00000022642 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Disintegrin and metalloproteinase domain-containing protein 28; May play a role in organogenesis and organ-specific functions such as thymic T-cell development. | 0.551 |