STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H2-T22Histocompatibility 2, T region locus 22; Belongs to the MHC class I family. (379 aa)    
Predicted Functional Partners:
Trgc3
T-cell receptor gamma chain C region C7.5.
    
   0.905
H2-Eb1
H-2 class II histocompatibility antigen, E-B beta chain; Belongs to the MHC class II family.
   
 0.850
H2-Aa
H-2 class II histocompatibility antigen, A-B alpha chain.
   
 0.826
B2m
Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system; Belongs to the beta-2-microglobulin family.
   
 0.826
H2-DMa
Class II histocompatibility antigen, M alpha chain; Plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides.
   
 
 0.812
Tapbp
Tapasin; Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
   
 0.789
H2-Oa
Histocompatibility 2, O region alpha locus; Belongs to the MHC class II family.
   
 
 0.782
H2-Q4
Histocompatibility 2, Q region locus 4; Belongs to the MHC class I family.
  
 
0.776
Cd74
H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44.
   
 
 0.776
H2-T23
H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system.
  
 
0.775
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.