node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
4921509C19Rik | Agtpbp1 | ENSMUSP00000079030 | ENSMUSP00000022040 | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | Cytosolic carboxypeptidase 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Deglutamylation plays a key role in cerebellar Purkinje cell dif [...] | 0.433 |
4921509C19Rik | Cplane1 | ENSMUSP00000079030 | ENSMUSP00000106247 | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | Ciliogenesis and planar polarity effector 1; Involved in ciliogenesis. Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies. | 0.574 |
4921509C19Rik | Iqcn | ENSMUSP00000079030 | ENSMUSP00000148728 | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | IQ motif-containing N. | 0.410 |
4921509C19Rik | Nsun7 | ENSMUSP00000079030 | ENSMUSP00000031109 | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | Putative methyltransferase NSUN7; May have S-adenosyl-L-methionine-dependent methyl-transferase activity. | 0.457 |
4921509C19Rik | Spag17 | ENSMUSP00000079030 | ENSMUSP00000134066 | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.439 |
4921509C19Rik | Spag8 | ENSMUSP00000079030 | ENSMUSP00000081696 | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau. Involved in the acrosome reaction and in binding of sperm to the zona pellucida. Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (By similarity). May play a role in fertility and microtubule formation through interaction with RANBP9 (By similarity). | 0.527 |
4921509C19Rik | Spata17 | ENSMUSP00000079030 | ENSMUSP00000138855 | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | Spermatogenesis-associated protein 17. | 0.523 |
4921509C19Rik | Spata4 | ENSMUSP00000079030 | ENSMUSP00000033917 | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | Spermatogenesis-associated protein 4; May play a role in apoptosis regulation. | 0.461 |
4921509C19Rik | Wdr88 | ENSMUSP00000079030 | ENSMUSP00000158765 | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | WD_REPEATS_REGION domain-containing protein. | 0.449 |
Agtpbp1 | 4921509C19Rik | ENSMUSP00000022040 | ENSMUSP00000079030 | Cytosolic carboxypeptidase 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Deglutamylation plays a key role in cerebellar Purkinje cell dif [...] | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | 0.433 |
Cplane1 | 4921509C19Rik | ENSMUSP00000106247 | ENSMUSP00000079030 | Ciliogenesis and planar polarity effector 1; Involved in ciliogenesis. Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies. | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | 0.574 |
Iqcn | 4921509C19Rik | ENSMUSP00000148728 | ENSMUSP00000079030 | IQ motif-containing N. | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | 0.410 |
Iqcn | Wdr88 | ENSMUSP00000148728 | ENSMUSP00000158765 | IQ motif-containing N. | WD_REPEATS_REGION domain-containing protein. | 0.414 |
Nsun7 | 4921509C19Rik | ENSMUSP00000031109 | ENSMUSP00000079030 | Putative methyltransferase NSUN7; May have S-adenosyl-L-methionine-dependent methyl-transferase activity. | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | 0.457 |
Spag17 | 4921509C19Rik | ENSMUSP00000134066 | ENSMUSP00000079030 | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | 0.439 |
Spag17 | Spag8 | ENSMUSP00000134066 | ENSMUSP00000081696 | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau. Involved in the acrosome reaction and in binding of sperm to the zona pellucida. Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (By similarity). May play a role in fertility and microtubule formation through interaction with RANBP9 (By similarity). | 0.567 |
Spag17 | Spata17 | ENSMUSP00000134066 | ENSMUSP00000138855 | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | Spermatogenesis-associated protein 17. | 0.630 |
Spag17 | Spata4 | ENSMUSP00000134066 | ENSMUSP00000033917 | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | Spermatogenesis-associated protein 4; May play a role in apoptosis regulation. | 0.540 |
Spag8 | 4921509C19Rik | ENSMUSP00000081696 | ENSMUSP00000079030 | Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau. Involved in the acrosome reaction and in binding of sperm to the zona pellucida. Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (By similarity). May play a role in fertility and microtubule formation through interaction with RANBP9 (By similarity). | Sperm motility kinase X; May play a role in sperm motility, especially in the regulation of flagellar function. | 0.527 |
Spag8 | Spag17 | ENSMUSP00000081696 | ENSMUSP00000134066 | Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau. Involved in the acrosome reaction and in binding of sperm to the zona pellucida. Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (By similarity). May play a role in fertility and microtubule formation through interaction with RANBP9 (By similarity). | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.567 |