node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gnat3 | Plcb2 | ENSMUSP00000030561 | ENSMUSP00000099583 | Guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP- phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultim [...] | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli (By similarity). | 0.991 |
Gnat3 | Tas1r2 | ENSMUSP00000030561 | ENSMUSP00000030510 | Guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP- phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultim [...] | Taste receptor type 1 member 2; Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. | 0.994 |
Gnat3 | Tas1r3 | ENSMUSP00000030561 | ENSMUSP00000030949 | Guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP- phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultim [...] | Taste receptor type 1 member 3; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. | 0.996 |
Gnat3 | Tas2r114 | ENSMUSP00000030561 | ENSMUSP00000079453 | Guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP- phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultim [...] | Taste receptor type 2 member 114; Putative taste receptor which may play a role in the perception of bitterness. | 0.546 |
Gnat3 | Trpm5 | ENSMUSP00000030561 | ENSMUSP00000009390 | Guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP- phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultim [...] | Transient receptor potential cation channel subfamily M member 5; Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). A [...] | 0.919 |
Olfr1364 | Ptpdc1 | ENSMUSP00000149964 | ENSMUSP00000047374 | Olfactory receptor. | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance. | 0.538 |
Olfr1364 | Tas2r114 | ENSMUSP00000149964 | ENSMUSP00000079453 | Olfactory receptor. | Taste receptor type 2 member 114; Putative taste receptor which may play a role in the perception of bitterness. | 0.556 |
Olfr639 | Ptpdc1 | ENSMUSP00000149743 | ENSMUSP00000047374 | Olfactory receptor. | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance. | 0.538 |
Olfr639 | Tas2r114 | ENSMUSP00000149743 | ENSMUSP00000079453 | Olfactory receptor. | Taste receptor type 2 member 114; Putative taste receptor which may play a role in the perception of bitterness. | 0.566 |
Olfr711 | Ptpdc1 | ENSMUSP00000149016 | ENSMUSP00000047374 | Olfactory receptor. | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance. | 0.538 |
Olfr711 | Tas2r114 | ENSMUSP00000149016 | ENSMUSP00000079453 | Olfactory receptor. | Taste receptor type 2 member 114; Putative taste receptor which may play a role in the perception of bitterness. | 0.550 |
Plcb2 | Gnat3 | ENSMUSP00000099583 | ENSMUSP00000030561 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli (By similarity). | Guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP- phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultim [...] | 0.991 |
Plcb2 | Tas1r2 | ENSMUSP00000099583 | ENSMUSP00000030510 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli (By similarity). | Taste receptor type 1 member 2; Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. | 0.810 |
Plcb2 | Tas1r3 | ENSMUSP00000099583 | ENSMUSP00000030949 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli (By similarity). | Taste receptor type 1 member 3; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. | 0.837 |
Plcb2 | Tas2r114 | ENSMUSP00000099583 | ENSMUSP00000079453 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli (By similarity). | Taste receptor type 2 member 114; Putative taste receptor which may play a role in the perception of bitterness. | 0.554 |
Plcb2 | Trpm5 | ENSMUSP00000099583 | ENSMUSP00000009390 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli (By similarity). | Transient receptor potential cation channel subfamily M member 5; Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). A [...] | 0.937 |
Prss37 | Tas2r114 | ENSMUSP00000031967 | ENSMUSP00000079453 | Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system (By similarity). | Taste receptor type 2 member 114; Putative taste receptor which may play a role in the perception of bitterness. | 0.523 |
Prss37 | Trpm5 | ENSMUSP00000031967 | ENSMUSP00000009390 | Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system (By similarity). | Transient receptor potential cation channel subfamily M member 5; Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). A [...] | 0.461 |
Ptpdc1 | Olfr1364 | ENSMUSP00000047374 | ENSMUSP00000149964 | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance. | Olfactory receptor. | 0.538 |
Ptpdc1 | Olfr639 | ENSMUSP00000047374 | ENSMUSP00000149743 | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance. | Olfactory receptor. | 0.538 |