STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Shisal1Protein shisa-like-1. (219 aa)    
Predicted Functional Partners:
Shisal2a
Protein shisa-like-2A.
      
 0.661
Cyyr1
Cysteine and tyrosine-rich protein 1.
   
  
 0.599
Wbp1
WW domain-binding protein 1.
      
 0.588
Llph
Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission.
      
 0.557
Tspyl4
Testis-specific Y-encoded-like protein 4; Belongs to the nucleosome assembly protein (NAP) family.
   
  
 0.521
Heatr6
HEAT repeat-containing protein 6.
      
 0.502
Shisal2b
Protein shisa-like-2B.
   
  
 0.492
Shisa3
Protein shisa-3 homolog; Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Belongs to the shisa family.
   
  
 0.492
Vopp1
Vesicular, overexpressed in cancer, prosurvival protein 1; Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.
      
 0.472
Ercc6l
DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
      
 0.463
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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