node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cetn1 | Plk1 | ENSMUSP00000057392 | ENSMUSP00000033154 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation ; Belongs to the centrin family. | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...] | 0.508 |
Cetn1 | Poc5 | ENSMUSP00000057392 | ENSMUSP00000096898 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation ; Belongs to the centrin family. | Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation. | 0.740 |
Cetn1 | Sfi1 | ENSMUSP00000057392 | ENSMUSP00000080066 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation ; Belongs to the centrin family. | Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. | 0.760 |
Cetn2 | Cetn3 | ENSMUSP00000110198 | ENSMUSP00000022009 | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortio [...] | Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function; Belongs to the centrin family. | 0.822 |
Cetn2 | Plk1 | ENSMUSP00000110198 | ENSMUSP00000033154 | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortio [...] | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...] | 0.887 |
Cetn2 | Poc5 | ENSMUSP00000110198 | ENSMUSP00000096898 | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortio [...] | Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation. | 0.798 |
Cetn2 | Sfi1 | ENSMUSP00000110198 | ENSMUSP00000080066 | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortio [...] | Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. | 0.842 |
Cetn3 | Cetn2 | ENSMUSP00000022009 | ENSMUSP00000110198 | Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function; Belongs to the centrin family. | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortio [...] | 0.822 |
Cetn3 | Poc5 | ENSMUSP00000022009 | ENSMUSP00000096898 | Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function; Belongs to the centrin family. | Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation. | 0.849 |
Cetn3 | Sfi1 | ENSMUSP00000022009 | ENSMUSP00000080066 | Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function; Belongs to the centrin family. | Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. | 0.821 |
Cetn4 | Poc5 | ENSMUSP00000100020 | ENSMUSP00000096898 | Centrin-4; Ca(2+)-binding protein that may be involved in basal body assembly or in a subsequent step of ciliogenesis. | Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation. | 0.470 |
Cetn4 | Sfi1 | ENSMUSP00000100020 | ENSMUSP00000080066 | Centrin-4; Ca(2+)-binding protein that may be involved in basal body assembly or in a subsequent step of ciliogenesis. | Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. | 0.724 |
Cramp1l | Sfi1 | ENSMUSP00000156906 | ENSMUSP00000080066 | Protein cramped-like. | Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. | 0.639 |
Crppa | Sfi1 | ENSMUSP00000061646 | ENSMUSP00000080066 | D-ribitol-5-phosphate cytidylyltransferase; Cytidylyltransferase required for protein O-linked mannosylation (By similarity). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (By similarity). CDP- ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3- N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By simil [...] | Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. | 0.693 |
Fbxw9 | Sfi1 | ENSMUSP00000092845 | ENSMUSP00000080066 | F-box and WD-40 domain protein 9. | Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. | 0.610 |
Plk1 | Cetn1 | ENSMUSP00000033154 | ENSMUSP00000057392 | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...] | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation ; Belongs to the centrin family. | 0.508 |
Plk1 | Cetn2 | ENSMUSP00000033154 | ENSMUSP00000110198 | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...] | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortio [...] | 0.887 |
Plk1 | Sfi1 | ENSMUSP00000033154 | ENSMUSP00000080066 | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...] | Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. | 0.843 |
Poc5 | Cetn1 | ENSMUSP00000096898 | ENSMUSP00000057392 | Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation. | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation ; Belongs to the centrin family. | 0.740 |
Poc5 | Cetn2 | ENSMUSP00000096898 | ENSMUSP00000110198 | Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation. | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortio [...] | 0.798 |