node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc12 | Cdc40 | ENSMUSP00000019803 | ENSMUSP00000044305 | Coiled-coil domain-containing protein 12. | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | 0.995 |
Ccdc12 | Cwc27 | ENSMUSP00000019803 | ENSMUSP00000022228 | Coiled-coil domain-containing protein 12. | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | 0.824 |
Ccdc12 | Ddx5 | ENSMUSP00000019803 | ENSMUSP00000021062 | Coiled-coil domain-containing protein 12. | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] | 0.807 |
Ccdc12 | Eif4a3 | ENSMUSP00000019803 | ENSMUSP00000026667 | Coiled-coil domain-containing protein 12. | Eukaryotic initiation factor 4A-III, N-terminally processed; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expr [...] | 0.814 |
Ccdc12 | Mtrex | ENSMUSP00000019803 | ENSMUSP00000022281 | Coiled-coil domain-containing protein 12. | Exosome RNA helicase MTR4; Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension. Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental f [...] | 0.800 |
Ccdc12 | Ppil1 | ENSMUSP00000019803 | ENSMUSP00000024802 | Coiled-coil domain-containing protein 12. | Peptidyl-prolyl cis-trans isomerase-like 1; Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. | 0.846 |
Ccdc12 | Ppil3 | ENSMUSP00000019803 | ENSMUSP00000112947 | Coiled-coil domain-containing protein 12. | Peptidyl-prolyl cis-trans isomerase-like 3; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity). Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily. | 0.856 |
Ccdc12 | Rnf113a1 | ENSMUSP00000019803 | ENSMUSP00000042569 | Coiled-coil domain-containing protein 12. | Ring finger protein 113A1. | 0.804 |
Ccdc12 | Slu7 | ENSMUSP00000019803 | ENSMUSP00000020681 | Coiled-coil domain-containing protein 12. | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family. | 0.804 |
Ccdc12 | Srrm2 | ENSMUSP00000019803 | ENSMUSP00000085993 | Coiled-coil domain-containing protein 12. | Serine/arginine repetitive matrix protein 2; Required for pre-mRNA splicing as component of the spliceosome; Belongs to the CWC21 family. | 0.816 |
Cdc40 | Ccdc12 | ENSMUSP00000044305 | ENSMUSP00000019803 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Coiled-coil domain-containing protein 12. | 0.995 |
Cdc40 | Cwc27 | ENSMUSP00000044305 | ENSMUSP00000022228 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | 0.972 |
Cdc40 | Ddx5 | ENSMUSP00000044305 | ENSMUSP00000021062 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] | 0.837 |
Cdc40 | Eif4a3 | ENSMUSP00000044305 | ENSMUSP00000026667 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Eukaryotic initiation factor 4A-III, N-terminally processed; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expr [...] | 0.910 |
Cdc40 | Mtrex | ENSMUSP00000044305 | ENSMUSP00000022281 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Exosome RNA helicase MTR4; Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension. Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental f [...] | 0.849 |
Cdc40 | Ppil1 | ENSMUSP00000044305 | ENSMUSP00000024802 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Peptidyl-prolyl cis-trans isomerase-like 1; Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. | 0.993 |
Cdc40 | Ppil3 | ENSMUSP00000044305 | ENSMUSP00000112947 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Peptidyl-prolyl cis-trans isomerase-like 3; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity). Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily. | 0.865 |
Cdc40 | Rnf113a1 | ENSMUSP00000044305 | ENSMUSP00000042569 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Ring finger protein 113A1. | 0.950 |
Cdc40 | Slu7 | ENSMUSP00000044305 | ENSMUSP00000020681 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family. | 0.997 |
Cdc40 | Srrm2 | ENSMUSP00000044305 | ENSMUSP00000085993 | Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome. | Serine/arginine repetitive matrix protein 2; Required for pre-mRNA splicing as component of the spliceosome; Belongs to the CWC21 family. | 0.974 |