node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc103 | Ccdc114 | ENSMUSP00000021307 | ENSMUSP00000042772 | Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | 0.840 |
Ccdc103 | Ccdc39 | ENSMUSP00000021307 | ENSMUSP00000029222 | Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. | 0.808 |
Ccdc103 | Dnaaf1 | ENSMUSP00000021307 | ENSMUSP00000090790 | Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. | Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity); Belongs to the DNAAF1 family. | 0.811 |
Ccdc103 | Dnah11 | ENSMUSP00000021307 | ENSMUSP00000081867 | Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. | Dynein, axonemal, heavy chain 11. | 0.713 |
Ccdc103 | Dnaic1 | ENSMUSP00000021307 | ENSMUSP00000100028 | Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. | Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia. | 0.859 |
Ccdc103 | Dnaic2 | ENSMUSP00000021307 | ENSMUSP00000065787 | Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. | Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia. | 0.888 |
Ccdc103 | Lrrc6 | ENSMUSP00000021307 | ENSMUSP00000023006 | Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility; Belongs to the tilB family. | 0.833 |
Ccdc103 | Nme8 | ENSMUSP00000021307 | ENSMUSP00000089358 | Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. | Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds (By similarity). | 0.811 |
Ccdc103 | Rsph4a | ENSMUSP00000021307 | ENSMUSP00000131647 | Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. | Radial spoke head protein 4 homolog A; Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. | 0.758 |
Ccdc103 | Rsph9 | ENSMUSP00000021307 | ENSMUSP00000024762 | Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. | Radial spoke head protein 9 homolog; Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. | 0.777 |
Ccdc114 | Ccdc103 | ENSMUSP00000042772 | ENSMUSP00000021307 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. | 0.840 |
Ccdc114 | Ccdc39 | ENSMUSP00000042772 | ENSMUSP00000029222 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. | 0.702 |
Ccdc114 | Dnaaf1 | ENSMUSP00000042772 | ENSMUSP00000090790 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity); Belongs to the DNAAF1 family. | 0.729 |
Ccdc114 | Dnah11 | ENSMUSP00000042772 | ENSMUSP00000081867 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein, axonemal, heavy chain 11. | 0.740 |
Ccdc114 | Dnaic1 | ENSMUSP00000042772 | ENSMUSP00000100028 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia. | 0.954 |
Ccdc114 | Dnaic2 | ENSMUSP00000042772 | ENSMUSP00000065787 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia. | 0.937 |
Ccdc114 | Lrrc6 | ENSMUSP00000042772 | ENSMUSP00000023006 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility; Belongs to the tilB family. | 0.690 |
Ccdc114 | Nme8 | ENSMUSP00000042772 | ENSMUSP00000089358 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds (By similarity). | 0.946 |
Ccdc114 | Rsph4a | ENSMUSP00000042772 | ENSMUSP00000131647 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Radial spoke head protein 4 homolog A; Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. | 0.829 |
Ccdc114 | Rsph9 | ENSMUSP00000042772 | ENSMUSP00000024762 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Radial spoke head protein 9 homolog; Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. | 0.660 |