node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gtf3c5 | Zfp64 | ENSMUSP00000109521 | ENSMUSP00000085285 | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters (By similarity); Belongs to the TFIIIC subunit 5 family. | Zinc finger protein 64; May be involved in transcriptional regulation. | 0.436 |
Htra3 | Zfp64 | ENSMUSP00000084910 | ENSMUSP00000085285 | Serine protease HTRA3; Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF- beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity). | Zinc finger protein 64; May be involved in transcriptional regulation. | 0.410 |
Jade1 | Zfp64 | ENSMUSP00000128152 | ENSMUSP00000085285 | Protein Jade-1; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (By similarity). Belongs to the JADE family. | Zinc finger protein 64; May be involved in transcriptional regulation. | 0.450 |
Phactr2 | Zfp64 | ENSMUSP00000101182 | ENSMUSP00000085285 | Phosphatase and actin regulator. | Zinc finger protein 64; May be involved in transcriptional regulation. | 0.428 |
Samd5 | Zfp64 | ENSMUSP00000097648 | ENSMUSP00000085285 | Sterile alpha motif domain-containing protein 5. | Zinc finger protein 64; May be involved in transcriptional regulation. | 0.446 |
Sec16b | Zfp64 | ENSMUSP00000083300 | ENSMUSP00000085285 | Protein transport protein Sec16B; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes; Belongs to the SEC16 family. | Zinc finger protein 64; May be involved in transcriptional regulation. | 0.429 |
Sik3 | Zfp64 | ENSMUSP00000121032 | ENSMUSP00000085285 | Serine/threonine-protein kinase SIK3; Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor (By similarity). Required for chondrocyte hypertrophy during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (By similarity). Prevents HDAC4 translocation to the nucleus. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. | Zinc finger protein 64; May be involved in transcriptional regulation. | 0.446 |
Zfp64 | Gtf3c5 | ENSMUSP00000085285 | ENSMUSP00000109521 | Zinc finger protein 64; May be involved in transcriptional regulation. | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters (By similarity); Belongs to the TFIIIC subunit 5 family. | 0.436 |
Zfp64 | Htra3 | ENSMUSP00000085285 | ENSMUSP00000084910 | Zinc finger protein 64; May be involved in transcriptional regulation. | Serine protease HTRA3; Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF- beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity). | 0.410 |
Zfp64 | Jade1 | ENSMUSP00000085285 | ENSMUSP00000128152 | Zinc finger protein 64; May be involved in transcriptional regulation. | Protein Jade-1; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (By similarity). Belongs to the JADE family. | 0.450 |
Zfp64 | Phactr2 | ENSMUSP00000085285 | ENSMUSP00000101182 | Zinc finger protein 64; May be involved in transcriptional regulation. | Phosphatase and actin regulator. | 0.428 |
Zfp64 | Samd5 | ENSMUSP00000085285 | ENSMUSP00000097648 | Zinc finger protein 64; May be involved in transcriptional regulation. | Sterile alpha motif domain-containing protein 5. | 0.446 |
Zfp64 | Sec16b | ENSMUSP00000085285 | ENSMUSP00000083300 | Zinc finger protein 64; May be involved in transcriptional regulation. | Protein transport protein Sec16B; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes; Belongs to the SEC16 family. | 0.429 |
Zfp64 | Sik3 | ENSMUSP00000085285 | ENSMUSP00000121032 | Zinc finger protein 64; May be involved in transcriptional regulation. | Serine/threonine-protein kinase SIK3; Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor (By similarity). Required for chondrocyte hypertrophy during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (By similarity). Prevents HDAC4 translocation to the nucleus. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. | 0.446 |