node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dner | Pnma2 | ENSMUSP00000042927 | ENSMUSP00000086646 | Delta and Notch-like epidermal growth factor-related receptor; Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling. | Paraneoplastic antigen Ma2 homolog; Belongs to the PNMA family. | 0.573 |
Dner | Zic4 | ENSMUSP00000042927 | ENSMUSP00000134053 | Delta and Notch-like epidermal growth factor-related receptor; Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling. | Zinc finger protein ZIC 4; Binds to DNA; Belongs to the GLI C2H2-type zinc-finger protein family. | 0.762 |
Fancm | Pnma2 | ENSMUSP00000054797 | ENSMUSP00000086646 | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | Paraneoplastic antigen Ma2 homolog; Belongs to the PNMA family. | 0.679 |
Fancm | Rtl6 | ENSMUSP00000054797 | ENSMUSP00000069947 | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | Retrotransposon Gag-like protein 6. | 0.679 |
Kctd20 | Mtcl1 | ENSMUSP00000156936 | ENSMUSP00000083899 | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family. | 0.606 |
Kctd20 | Pnma2 | ENSMUSP00000156936 | ENSMUSP00000086646 | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | Paraneoplastic antigen Ma2 homolog; Belongs to the PNMA family. | 0.635 |
Kctd20 | Ppp2r1a | ENSMUSP00000156936 | ENSMUSP00000007708 | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity). | 0.528 |
Kctd20 | Ywhab | ENSMUSP00000156936 | ENSMUSP00000018470 | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] | 0.530 |
Kctd20 | Ywhah | ENSMUSP00000156936 | ENSMUSP00000019109 | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | 14-3-3 protein eta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.518 |
Mtcl1 | Kctd20 | ENSMUSP00000083899 | ENSMUSP00000156936 | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family. | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | 0.606 |
Mtcl1 | Pnma2 | ENSMUSP00000083899 | ENSMUSP00000086646 | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family. | Paraneoplastic antigen Ma2 homolog; Belongs to the PNMA family. | 0.588 |
Mtcl1 | Ppp2r1a | ENSMUSP00000083899 | ENSMUSP00000007708 | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family. | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity). | 0.510 |
Mtcl1 | Ywhab | ENSMUSP00000083899 | ENSMUSP00000018470 | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family. | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] | 0.517 |
Pnma2 | Dner | ENSMUSP00000086646 | ENSMUSP00000042927 | Paraneoplastic antigen Ma2 homolog; Belongs to the PNMA family. | Delta and Notch-like epidermal growth factor-related receptor; Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling. | 0.573 |
Pnma2 | Fancm | ENSMUSP00000086646 | ENSMUSP00000054797 | Paraneoplastic antigen Ma2 homolog; Belongs to the PNMA family. | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | 0.679 |
Pnma2 | Kctd20 | ENSMUSP00000086646 | ENSMUSP00000156936 | Paraneoplastic antigen Ma2 homolog; Belongs to the PNMA family. | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members. | 0.635 |
Pnma2 | Mtcl1 | ENSMUSP00000086646 | ENSMUSP00000083899 | Paraneoplastic antigen Ma2 homolog; Belongs to the PNMA family. | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family. | 0.588 |
Pnma2 | Ppp2r1a | ENSMUSP00000086646 | ENSMUSP00000007708 | Paraneoplastic antigen Ma2 homolog; Belongs to the PNMA family. | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity). | 0.591 |
Pnma2 | Rtl6 | ENSMUSP00000086646 | ENSMUSP00000069947 | Paraneoplastic antigen Ma2 homolog; Belongs to the PNMA family. | Retrotransposon Gag-like protein 6. | 0.669 |
Pnma2 | Ywhab | ENSMUSP00000086646 | ENSMUSP00000018470 | Paraneoplastic antigen Ma2 homolog; Belongs to the PNMA family. | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] | 0.544 |