STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gpr15G-protein coupled receptor 15; Probable chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (360 aa)    
Predicted Functional Partners:
2610528A11Rik
Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (By similarity).
      
 0.792
Cldnd1
Claudin domain-containing protein 1.
      
 0.608
Gpr45
Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function.
     
 0.601
Gpr150
Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.580
Gpr27
Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity).
     
 0.547
Lrrn3
Leucine-rich repeat neuronal protein 3.
      
 0.483
Gpr25
Probable G-protein coupled receptor 25; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
   
 
0.474
Gpr84
G-protein coupled receptor 84; Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system (By similarity).
   
 
0.473
Gpr176
G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production.
     
 0.472
Gpr83
Probable G-protein coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor.
     
0.463
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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