node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ager | Fam13a | ENSMUSP00000015596 | ENSMUSP00000087304 | Advanced glycosylation end product-specific receptor; Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1 [...] | Protein FAM13A. | 0.595 |
Ager | Gstcd | ENSMUSP00000015596 | ENSMUSP00000029651 | Advanced glycosylation end product-specific receptor; Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1 [...] | Glutathione S-transferase C-terminal domain-containing protein; Belongs to the GSTCD family. | 0.554 |
Ager | Hhip | ENSMUSP00000015596 | ENSMUSP00000078047 | Advanced glycosylation end product-specific receptor; Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1 [...] | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types, including brain and lung through direct interaction with members of the hedgehog family. Soluble forms inhibit Shh-induced differentiation in the fibroblast cell line C3H/10T1/2; Belongs to the HHIP family. | 0.451 |
Armc2 | Fam13a | ENSMUSP00000125583 | ENSMUSP00000087304 | Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function. Involved in axonemal central pair complex assembly and/or stability. | Protein FAM13A. | 0.532 |
Armc2 | Gstcd | ENSMUSP00000125583 | ENSMUSP00000029651 | Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function. Involved in axonemal central pair complex assembly and/or stability. | Glutathione S-transferase C-terminal domain-containing protein; Belongs to the GSTCD family. | 0.451 |
Chrna5 | Fam13a | ENSMUSP00000091365 | ENSMUSP00000087304 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub- subfamily. | Protein FAM13A. | 0.607 |
Chrna5 | Gstcd | ENSMUSP00000091365 | ENSMUSP00000029651 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub- subfamily. | Glutathione S-transferase C-terminal domain-containing protein; Belongs to the GSTCD family. | 0.417 |
Chrna5 | Hhip | ENSMUSP00000091365 | ENSMUSP00000078047 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub- subfamily. | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types, including brain and lung through direct interaction with members of the hedgehog family. Soluble forms inhibit Shh-induced differentiation in the fibroblast cell line C3H/10T1/2; Belongs to the HHIP family. | 0.471 |
Chrna5 | Ireb2 | ENSMUSP00000091365 | ENSMUSP00000034843 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub- subfamily. | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. | 0.550 |
Chrna5 | Rin3 | ENSMUSP00000091365 | ENSMUSP00000060771 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub- subfamily. | Ras and Rab interactor 3; Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function (By similarity). | 0.402 |
Fam13a | Ager | ENSMUSP00000087304 | ENSMUSP00000015596 | Protein FAM13A. | Advanced glycosylation end product-specific receptor; Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1 [...] | 0.595 |
Fam13a | Armc2 | ENSMUSP00000087304 | ENSMUSP00000125583 | Protein FAM13A. | Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function. Involved in axonemal central pair complex assembly and/or stability. | 0.532 |
Fam13a | Chrna5 | ENSMUSP00000087304 | ENSMUSP00000091365 | Protein FAM13A. | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub- subfamily. | 0.607 |
Fam13a | Fam184b | ENSMUSP00000087304 | ENSMUSP00000016023 | Protein FAM13A. | Protein FAM184B. | 0.525 |
Fam13a | Gstcd | ENSMUSP00000087304 | ENSMUSP00000029651 | Protein FAM13A. | Glutathione S-transferase C-terminal domain-containing protein; Belongs to the GSTCD family. | 0.670 |
Fam13a | Hhip | ENSMUSP00000087304 | ENSMUSP00000078047 | Protein FAM13A. | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types, including brain and lung through direct interaction with members of the hedgehog family. Soluble forms inhibit Shh-induced differentiation in the fibroblast cell line C3H/10T1/2; Belongs to the HHIP family. | 0.804 |
Fam13a | Ireb2 | ENSMUSP00000087304 | ENSMUSP00000034843 | Protein FAM13A. | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. | 0.761 |
Fam13a | Pigyl | ENSMUSP00000087304 | ENSMUSP00000116929 | Protein FAM13A. | Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y; Component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. May act by regulating the catalytic subunit PIGA (By similarity). | 0.651 |
Fam13a | Pyurf | ENSMUSP00000087304 | ENSMUSP00000050958 | Protein FAM13A. | Protein preY, mitochondrial. | 0.558 |
Fam13a | Rin3 | ENSMUSP00000087304 | ENSMUSP00000060771 | Protein FAM13A. | Ras and Rab interactor 3; Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function (By similarity). | 0.614 |