node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Snap23 | Stx11 | ENSMUSP00000112138 | ENSMUSP00000046243 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | 0.994 |
Snap23 | Stx1a | ENSMUSP00000112138 | ENSMUSP00000005509 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. | Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] | 0.991 |
Snap23 | Stx1b | ENSMUSP00000112138 | ENSMUSP00000101874 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. | Syntaxin-1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm; Belongs to the syntaxin family. | 0.950 |
Snap23 | Stx2 | ENSMUSP00000112138 | ENSMUSP00000031378 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. | Syntaxin-2; Essential for epithelial morphogenesis. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm. | 0.993 |
Snap23 | Stx3 | ENSMUSP00000112138 | ENSMUSP00000069529 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. | Syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. | 0.999 |
Snap23 | Stx4a | ENSMUSP00000112138 | ENSMUSP00000033075 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. | 0.999 |
Snap23 | Stxbp3 | ENSMUSP00000112138 | ENSMUSP00000099681 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. | Syntaxin-binding protein 3; Together with STX4 and VAMP2, may play a role in insulin- dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. | 0.894 |
Snap23 | Vamp2 | ENSMUSP00000112138 | ENSMUSP00000021273 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. | Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity); Belongs to the synaptobrevin family. | 0.999 |
Snap23 | Vamp3 | ENSMUSP00000112138 | ENSMUSP00000030797 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. | Vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the synaptobrevin family. | 0.999 |
Snap23 | Vamp8 | ENSMUSP00000112138 | ENSMUSP00000059501 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex (By similarity). Also required for dense-granule secretion in plat [...] | 0.999 |
Stx11 | Snap23 | ENSMUSP00000046243 | ENSMUSP00000112138 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. | 0.994 |
Stx11 | Stx1a | ENSMUSP00000046243 | ENSMUSP00000005509 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] | 0.561 |
Stx11 | Stx1b | ENSMUSP00000046243 | ENSMUSP00000101874 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Syntaxin-1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm; Belongs to the syntaxin family. | 0.566 |
Stx11 | Stx2 | ENSMUSP00000046243 | ENSMUSP00000031378 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Syntaxin-2; Essential for epithelial morphogenesis. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm. | 0.585 |
Stx11 | Stx3 | ENSMUSP00000046243 | ENSMUSP00000069529 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. | 0.734 |
Stx11 | Stx4a | ENSMUSP00000046243 | ENSMUSP00000033075 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. | 0.617 |
Stx11 | Stxbp3 | ENSMUSP00000046243 | ENSMUSP00000099681 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Syntaxin-binding protein 3; Together with STX4 and VAMP2, may play a role in insulin- dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. | 0.710 |
Stx11 | Vamp2 | ENSMUSP00000046243 | ENSMUSP00000021273 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity); Belongs to the synaptobrevin family. | 0.925 |
Stx11 | Vamp3 | ENSMUSP00000046243 | ENSMUSP00000030797 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the synaptobrevin family. | 0.897 |
Stx11 | Vamp8 | ENSMUSP00000046243 | ENSMUSP00000059501 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex (By similarity). Also required for dense-granule secretion in plat [...] | 0.979 |