STRINGSTRING
Akr1e1 protein (mouse) - STRING interaction network
"Akr1e1" - Aldo-keto reductase family 1, member E1 in Mus musculus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Akr1e1Aldo-keto reductase family 1, member E1; Catalyzes the NADPH-dependent reduction of 1,5-anhydro- D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones (301 aa)    
Predicted Functional Partners:
Grhpr
Glyoxylate reductase/hydroxypyruvate reductase; Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate (By similarity) (328 aa)
   
  0.706
Aldh16a1
Aldehyde dehydrogenase 16 family, member A1 (802 aa)
     
  0.684
Aldh5a1
Aldhehyde dehydrogenase family 5, subfamily A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) (523 aa)
     
  0.633
Aldh8a1
Aldehyde dehydrogenase 8 family, member A1; Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has a preference for NAD, but shows considerable activity with NADP (in vitro) (By similarity) (487 aa)
     
  0.633
Aldh1b1
Aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (By similarity) (519 aa)
     
  0.633
Aldh1a7
Aldehyde dehydrogenase family 1, subfamily A7; Can oxidize benzaldehyde, propionaldehyde and acetaldehyde (By similarity). No detectable activity with retinal (501 aa)
     
  0.621
Aldh1l1
Aldehyde dehydrogenase 1 family, member L1 (902 aa)
     
  0.620
Aldh9a1
Aldehyde dehydrogenase 9, subfamily A1; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine (518 aa)
     
  0.609
Aldh7a1
Aldehyde dehydrogenase family 7, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity) (539 aa)
     
  0.603
Aldh4a1
Aldehyde dehydrogenase 4 family, member A1; Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity) (562 aa)
     
  0.601
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mice, mouse, nude mice, transgenic mice
Server load: low (9%) [HD]