node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akr1e1 | Akr7a5 | ENSMUSP00000089459 | ENSMUSP00000073459 | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | Aflatoxin B1 aldehyde reductase member 2; Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity). | 0.457 |
Akr1e1 | CK137956 | ENSMUSP00000089459 | ENSMUSP00000030614 | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | cDNA sequence CK137956. | 0.578 |
Akr1e1 | Cbr4 | ENSMUSP00000089459 | ENSMUSP00000034058 | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | Carbonyl reductase family member 4; The heterotetramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. The homotetramer has NADPH-dependent quinone reductase activity. Both homotetramer and the heterotetramer have broad in vitro substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o- quinones and p-quinones; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.605 |
Akr1e1 | Fam162b | ENSMUSP00000089459 | ENSMUSP00000020064 | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | Protein FAM162B. | 0.578 |
Akr1e1 | Galntl6 | ENSMUSP00000089459 | ENSMUSP00000145321 | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | Polypeptide N-acetylgalactosaminyltransferase. | 0.587 |
Akr1e1 | Hs6st3 | ENSMUSP00000089459 | ENSMUSP00000070394 | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | Heparan-sulfate 6-O-sulfotransferase 3; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | 0.512 |
Akr1e1 | Mfsd6l | ENSMUSP00000089459 | ENSMUSP00000061601 | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | Major facilitator superfamily domain-containing protein 6-like. | 0.477 |
Akr1e1 | Rex2 | ENSMUSP00000089459 | ENSMUSP00000075179 | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | Reduced expression 2. | 0.715 |
Akr1e1 | Zfp985 | ENSMUSP00000089459 | ENSMUSP00000080438 | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | Zinc finger protein 985. | 0.484 |
Akr1e1 | Zpld1 | ENSMUSP00000089459 | ENSMUSP00000119774 | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | Zona pellucida-like domain-containing protein 1, secreted form; Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ. | 0.544 |
Akr7a5 | Akr1e1 | ENSMUSP00000073459 | ENSMUSP00000089459 | Aflatoxin B1 aldehyde reductase member 2; Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity). | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | 0.457 |
CK137956 | Akr1e1 | ENSMUSP00000030614 | ENSMUSP00000089459 | cDNA sequence CK137956. | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | 0.578 |
Cbr4 | Akr1e1 | ENSMUSP00000034058 | ENSMUSP00000089459 | Carbonyl reductase family member 4; The heterotetramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. The homotetramer has NADPH-dependent quinone reductase activity. Both homotetramer and the heterotetramer have broad in vitro substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o- quinones and p-quinones; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | 0.605 |
Fam162b | Akr1e1 | ENSMUSP00000020064 | ENSMUSP00000089459 | Protein FAM162B. | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | 0.578 |
Fam162b | Galntl6 | ENSMUSP00000020064 | ENSMUSP00000145321 | Protein FAM162B. | Polypeptide N-acetylgalactosaminyltransferase. | 0.592 |
Fam162b | Hs6st3 | ENSMUSP00000020064 | ENSMUSP00000070394 | Protein FAM162B. | Heparan-sulfate 6-O-sulfotransferase 3; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | 0.517 |
Fam162b | Zpld1 | ENSMUSP00000020064 | ENSMUSP00000119774 | Protein FAM162B. | Zona pellucida-like domain-containing protein 1, secreted form; Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ. | 0.544 |
Galntl6 | Akr1e1 | ENSMUSP00000145321 | ENSMUSP00000089459 | Polypeptide N-acetylgalactosaminyltransferase. | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family. | 0.587 |
Galntl6 | Fam162b | ENSMUSP00000145321 | ENSMUSP00000020064 | Polypeptide N-acetylgalactosaminyltransferase. | Protein FAM162B. | 0.592 |
Galntl6 | Hs6st3 | ENSMUSP00000145321 | ENSMUSP00000070394 | Polypeptide N-acetylgalactosaminyltransferase. | Heparan-sulfate 6-O-sulfotransferase 3; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | 0.523 |