node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dhx35 | Hmgxb3 | ENSMUSP00000029186 | ENSMUSP00000089498 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | HMG box domain-containing 3. | 0.571 |
Dhx35 | Morc2a | ENSMUSP00000029186 | ENSMUSP00000094176 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | ATPase MORC2A; Essential for epigenetic silencing by the HUSH complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (By similarity). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down- regulation of host gene expression. During DNA damage response, regula [...] | 0.585 |
Dhx35 | Polr3a | ENSMUSP00000029186 | ENSMUSP00000026322 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.408 |
Hmgxb3 | Dhx35 | ENSMUSP00000089498 | ENSMUSP00000029186 | HMG box domain-containing 3. | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | 0.571 |
Hmgxb3 | Morc2a | ENSMUSP00000089498 | ENSMUSP00000094176 | HMG box domain-containing 3. | ATPase MORC2A; Essential for epigenetic silencing by the HUSH complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (By similarity). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down- regulation of host gene expression. During DNA damage response, regula [...] | 0.625 |
Hmgxb3 | Nadk2 | ENSMUSP00000089498 | ENSMUSP00000068318 | HMG box domain-containing 3. | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor (By similarity). | 0.522 |
Hmgxb3 | Nrsn2 | ENSMUSP00000089498 | ENSMUSP00000078260 | HMG box domain-containing 3. | Neurensin-2; May play a role in maintenance and/or transport of vesicles. Belongs to the VMP family. | 0.529 |
Hmgxb3 | Polr3a | ENSMUSP00000089498 | ENSMUSP00000026322 | HMG box domain-containing 3. | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.418 |
Hmgxb3 | Pwwp2a | ENSMUSP00000089498 | ENSMUSP00000054154 | HMG box domain-containing 3. | PWWP domain-containing protein 2A; H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. Also required for proper mitosis progression. | 0.525 |
Hmgxb3 | Slc26a2 | ENSMUSP00000089498 | ENSMUSP00000119447 | HMG box domain-containing 3. | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation. | 0.602 |
Hmgxb3 | Xpo5 | ENSMUSP00000089498 | ENSMUSP00000084257 | HMG box domain-containing 3. | Exportin-5; Mediates the nuclear export of proteins bearing a double- stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of [...] | 0.441 |
Hmgxb3 | Zcchc8 | ENSMUSP00000089498 | ENSMUSP00000142363 | HMG box domain-containing 3. | Zinc finger CCHC domain-containing protein 8; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. May be involved in pre-mRNA splicing. | 0.461 |
Hmgxb3 | Zfp335 | ENSMUSP00000089498 | ENSMUSP00000038298 | HMG box domain-containing 3. | Zinc finger protein 335; Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand- dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation; Belongs to the krueppel C2H2 [...] | 0.512 |
Morc2a | Dhx35 | ENSMUSP00000094176 | ENSMUSP00000029186 | ATPase MORC2A; Essential for epigenetic silencing by the HUSH complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (By similarity). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down- regulation of host gene expression. During DNA damage response, regula [...] | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | 0.585 |
Morc2a | Hmgxb3 | ENSMUSP00000094176 | ENSMUSP00000089498 | ATPase MORC2A; Essential for epigenetic silencing by the HUSH complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (By similarity). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down- regulation of host gene expression. During DNA damage response, regula [...] | HMG box domain-containing 3. | 0.625 |
Nadk2 | Hmgxb3 | ENSMUSP00000068318 | ENSMUSP00000089498 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor (By similarity). | HMG box domain-containing 3. | 0.522 |
Nrsn2 | Hmgxb3 | ENSMUSP00000078260 | ENSMUSP00000089498 | Neurensin-2; May play a role in maintenance and/or transport of vesicles. Belongs to the VMP family. | HMG box domain-containing 3. | 0.529 |
Polr3a | Dhx35 | ENSMUSP00000026322 | ENSMUSP00000029186 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | 0.408 |
Polr3a | Hmgxb3 | ENSMUSP00000026322 | ENSMUSP00000089498 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | HMG box domain-containing 3. | 0.418 |
Pwwp2a | Hmgxb3 | ENSMUSP00000054154 | ENSMUSP00000089498 | PWWP domain-containing protein 2A; H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. Also required for proper mitosis progression. | HMG box domain-containing 3. | 0.525 |