node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C2cd2 | Dennd5a | ENSMUSP00000127368 | ENSMUSP00000079295 | C2 domain-containing protein 2. | DENN domain-containing protein 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth (By similarity); Belongs to the RAB6IP1 family. | 0.493 |
C2cd2 | Lca5 | ENSMUSP00000127368 | ENSMUSP00000034791 | C2 domain-containing protein 2. | Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. | 0.653 |
C2cd2 | Shisa8 | ENSMUSP00000127368 | ENSMUSP00000137002 | C2 domain-containing protein 2. | Protein shisa-8; May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses. | 0.792 |
C2cd2 | Tspear | ENSMUSP00000127368 | ENSMUSP00000090020 | C2 domain-containing protein 2. | Thrombospondin-type laminin G domain and EAR repeat-containing protein; Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system. | 0.726 |
C2cd2 | Ybey | ENSMUSP00000127368 | ENSMUSP00000045647 | C2 domain-containing protein 2. | Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation; Belongs to the endoribonuclease YbeY family. | 0.612 |
Ceacam16 | Espn | ENSMUSP00000014830 | ENSMUSP00000030785 | Carcinoembryonic antigen-related cell adhesion molecule 16; Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane; Belongs to the immunoglobulin superfamily. CEA family. | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | 0.707 |
Ceacam16 | Smpx | ENSMUSP00000014830 | ENSMUSP00000140268 | Carcinoembryonic antigen-related cell adhesion molecule 16; Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane; Belongs to the immunoglobulin superfamily. CEA family. | Small muscular protein; Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair; Belongs to the SMPX family. | 0.663 |
Ceacam16 | Strc | ENSMUSP00000014830 | ENSMUSP00000039378 | Carcinoembryonic antigen-related cell adhesion molecule 16; Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane; Belongs to the immunoglobulin superfamily. CEA family. | Stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia. | 0.790 |
Ceacam16 | Tspear | ENSMUSP00000014830 | ENSMUSP00000090020 | Carcinoembryonic antigen-related cell adhesion molecule 16; Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane; Belongs to the immunoglobulin superfamily. CEA family. | Thrombospondin-type laminin G domain and EAR repeat-containing protein; Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system. | 0.778 |
Ceacam16 | Whrn | ENSMUSP00000014830 | ENSMUSP00000081557 | Carcinoembryonic antigen-related cell adhesion molecule 16; Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane; Belongs to the immunoglobulin superfamily. CEA family. | Whirlin; Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. | 0.715 |
Dennd5a | C2cd2 | ENSMUSP00000079295 | ENSMUSP00000127368 | DENN domain-containing protein 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth (By similarity); Belongs to the RAB6IP1 family. | C2 domain-containing protein 2. | 0.493 |
Dennd5a | Lca5 | ENSMUSP00000079295 | ENSMUSP00000034791 | DENN domain-containing protein 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth (By similarity); Belongs to the RAB6IP1 family. | Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. | 0.463 |
Dennd5a | Tspear | ENSMUSP00000079295 | ENSMUSP00000090020 | DENN domain-containing protein 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth (By similarity); Belongs to the RAB6IP1 family. | Thrombospondin-type laminin G domain and EAR repeat-containing protein; Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system. | 0.645 |
Dennd5a | Ybey | ENSMUSP00000079295 | ENSMUSP00000045647 | DENN domain-containing protein 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth (By similarity); Belongs to the RAB6IP1 family. | Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation; Belongs to the endoribonuclease YbeY family. | 0.653 |
Espn | Ceacam16 | ENSMUSP00000030785 | ENSMUSP00000014830 | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | Carcinoembryonic antigen-related cell adhesion molecule 16; Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane; Belongs to the immunoglobulin superfamily. CEA family. | 0.707 |
Espn | Strc | ENSMUSP00000030785 | ENSMUSP00000039378 | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | Stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia. | 0.767 |
Espn | Tspear | ENSMUSP00000030785 | ENSMUSP00000090020 | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | Thrombospondin-type laminin G domain and EAR repeat-containing protein; Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system. | 0.634 |
Espn | Whrn | ENSMUSP00000030785 | ENSMUSP00000081557 | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | Whirlin; Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. | 0.965 |
Lca5 | C2cd2 | ENSMUSP00000034791 | ENSMUSP00000127368 | Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. | C2 domain-containing protein 2. | 0.653 |
Lca5 | Dennd5a | ENSMUSP00000034791 | ENSMUSP00000079295 | Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. | DENN domain-containing protein 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth (By similarity); Belongs to the RAB6IP1 family. | 0.463 |