node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dnajb1 | Hsf3 | ENSMUSP00000005620 | ENSMUSP00000052508 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Heat shock factor protein 3; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription of non-classical heat-shock genes such as PDZD2 and PROM2. Protects cells against heat shock and proteotoxic stress; Belongs to the HSF family. | 0.481 |
Dnajb1 | Hsf5 | ENSMUSP00000005620 | ENSMUSP00000091488 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Heat shock factor protein 5; May act as a transcriptional factor. | 0.515 |
Dnajb1 | Hspa12a | ENSMUSP00000005620 | ENSMUSP00000066860 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Heat shock 70 kDa protein 12A; Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. Belongs to the heat shock protein 70 family. | 0.685 |
Dnajb1 | Hspa1b | ENSMUSP00000005620 | ENSMUSP00000133815 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Heat shock 70 kDa protein 1B; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...] | 0.999 |
Dnajb1 | Hspa4 | ENSMUSP00000005620 | ENSMUSP00000020630 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.994 |
Dnajb1 | Hspb7 | ENSMUSP00000005620 | ENSMUSP00000099544 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Heat shock protein beta-7. | 0.482 |
Dnajb1 | Hyou1 | ENSMUSP00000005620 | ENSMUSP00000123700 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Hypoxia up-regulated protein 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding (By similarity). | 0.650 |
Dnajb13 | Hsf5 | ENSMUSP00000147019 | ENSMUSP00000091488 | DnaJ homolog subfamily B member 13; Plays a role in the formation of the central complex of ciliary and flagellar axonemes. | Heat shock factor protein 5; May act as a transcriptional factor. | 0.401 |
Dnajb13 | Hspa12a | ENSMUSP00000147019 | ENSMUSP00000066860 | DnaJ homolog subfamily B member 13; Plays a role in the formation of the central complex of ciliary and flagellar axonemes. | Heat shock 70 kDa protein 12A; Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. Belongs to the heat shock protein 70 family. | 0.470 |
Dnajb13 | Hspa1b | ENSMUSP00000147019 | ENSMUSP00000133815 | DnaJ homolog subfamily B member 13; Plays a role in the formation of the central complex of ciliary and flagellar axonemes. | Heat shock 70 kDa protein 1B; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...] | 0.696 |
Dnajb13 | Hspa4 | ENSMUSP00000147019 | ENSMUSP00000020630 | DnaJ homolog subfamily B member 13; Plays a role in the formation of the central complex of ciliary and flagellar axonemes. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.615 |
Hrc | Hsf3 | ENSMUSP00000082459 | ENSMUSP00000052508 | Histidine-rich calcium-binding protein. | Heat shock factor protein 3; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription of non-classical heat-shock genes such as PDZD2 and PROM2. Protects cells against heat shock and proteotoxic stress; Belongs to the HSF family. | 0.558 |
Hrc | Hsf5 | ENSMUSP00000082459 | ENSMUSP00000091488 | Histidine-rich calcium-binding protein. | Heat shock factor protein 5; May act as a transcriptional factor. | 0.518 |
Hsf3 | Dnajb1 | ENSMUSP00000052508 | ENSMUSP00000005620 | Heat shock factor protein 3; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription of non-classical heat-shock genes such as PDZD2 and PROM2. Protects cells against heat shock and proteotoxic stress; Belongs to the HSF family. | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | 0.481 |
Hsf3 | Hrc | ENSMUSP00000052508 | ENSMUSP00000082459 | Heat shock factor protein 3; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription of non-classical heat-shock genes such as PDZD2 and PROM2. Protects cells against heat shock and proteotoxic stress; Belongs to the HSF family. | Histidine-rich calcium-binding protein. | 0.558 |
Hsf3 | Hsf5 | ENSMUSP00000052508 | ENSMUSP00000091488 | Heat shock factor protein 3; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription of non-classical heat-shock genes such as PDZD2 and PROM2. Protects cells against heat shock and proteotoxic stress; Belongs to the HSF family. | Heat shock factor protein 5; May act as a transcriptional factor. | 0.741 |
Hsf3 | Hspa1b | ENSMUSP00000052508 | ENSMUSP00000133815 | Heat shock factor protein 3; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription of non-classical heat-shock genes such as PDZD2 and PROM2. Protects cells against heat shock and proteotoxic stress; Belongs to the HSF family. | Heat shock 70 kDa protein 1B; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...] | 0.582 |
Hsf3 | Hspa4 | ENSMUSP00000052508 | ENSMUSP00000020630 | Heat shock factor protein 3; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription of non-classical heat-shock genes such as PDZD2 and PROM2. Protects cells against heat shock and proteotoxic stress; Belongs to the HSF family. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.450 |
Hsf5 | Dnajb1 | ENSMUSP00000091488 | ENSMUSP00000005620 | Heat shock factor protein 5; May act as a transcriptional factor. | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | 0.515 |
Hsf5 | Dnajb13 | ENSMUSP00000091488 | ENSMUSP00000147019 | Heat shock factor protein 5; May act as a transcriptional factor. | DnaJ homolog subfamily B member 13; Plays a role in the formation of the central complex of ciliary and flagellar axonemes. | 0.401 |