node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akap1 | Asb8 | ENSMUSP00000018572 | ENSMUSP00000115813 | A-kinase anchor protein 1, mitochondrial; Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4 [...] | Ankyrin repeat and SOCS box protein 8; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | 0.440 |
Akap1 | Fam217b | ENSMUSP00000018572 | ENSMUSP00000091805 | A-kinase anchor protein 1, mitochondrial; Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4 [...] | Family with sequence similarity 217, member B. | 0.564 |
Asb8 | Akap1 | ENSMUSP00000115813 | ENSMUSP00000018572 | Ankyrin repeat and SOCS box protein 8; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | A-kinase anchor protein 1, mitochondrial; Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4 [...] | 0.440 |
Asb8 | Fam217b | ENSMUSP00000115813 | ENSMUSP00000091805 | Ankyrin repeat and SOCS box protein 8; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | Family with sequence similarity 217, member B. | 0.733 |
Asb8 | Lrrc28 | ENSMUSP00000115813 | ENSMUSP00000052177 | Ankyrin repeat and SOCS box protein 8; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | Leucine-rich repeat-containing protein 28. | 0.620 |
Fam217b | Akap1 | ENSMUSP00000091805 | ENSMUSP00000018572 | Family with sequence similarity 217, member B. | A-kinase anchor protein 1, mitochondrial; Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4 [...] | 0.564 |
Fam217b | Asb8 | ENSMUSP00000091805 | ENSMUSP00000115813 | Family with sequence similarity 217, member B. | Ankyrin repeat and SOCS box protein 8; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | 0.733 |
Fam217b | Ift46 | ENSMUSP00000091805 | ENSMUSP00000002099 | Family with sequence similarity 217, member B. | Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis. | 0.570 |
Fam217b | Lrrc28 | ENSMUSP00000091805 | ENSMUSP00000052177 | Family with sequence similarity 217, member B. | Leucine-rich repeat-containing protein 28. | 0.755 |
Fam217b | Manea | ENSMUSP00000091805 | ENSMUSP00000038671 | Family with sequence similarity 217, member B. | Glycoprotein endo-alpha-1,2-mannosidase. | 0.489 |
Fam217b | Nck1 | ENSMUSP00000091805 | ENSMUSP00000112221 | Family with sequence similarity 217, member B. | Cytoplasmic protein NCK1; Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA (By similarity). | 0.476 |
Fam217b | Phactr3 | ENSMUSP00000091805 | ENSMUSP00000104543 | Family with sequence similarity 217, member B. | Phosphatase and actin regulator 3. | 0.428 |
Fam217b | Ppp1r3d | ENSMUSP00000091805 | ENSMUSP00000061402 | Family with sequence similarity 217, member B. | Protein phosphatase 1, regulatory subunit 3D. | 0.816 |
Fam217b | Wrap73 | ENSMUSP00000091805 | ENSMUSP00000030895 | Family with sequence similarity 217, member B. | WD repeat-containing protein WRAP73; The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal bo [...] | 0.483 |
Fam217b | Zfp931 | ENSMUSP00000091805 | ENSMUSP00000104552 | Family with sequence similarity 217, member B. | Zinc finger protein 931. | 0.695 |
Ift46 | Fam217b | ENSMUSP00000002099 | ENSMUSP00000091805 | Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis. | Family with sequence similarity 217, member B. | 0.570 |
Lrrc28 | Asb8 | ENSMUSP00000052177 | ENSMUSP00000115813 | Leucine-rich repeat-containing protein 28. | Ankyrin repeat and SOCS box protein 8; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | 0.620 |
Lrrc28 | Fam217b | ENSMUSP00000052177 | ENSMUSP00000091805 | Leucine-rich repeat-containing protein 28. | Family with sequence similarity 217, member B. | 0.755 |
Manea | Fam217b | ENSMUSP00000038671 | ENSMUSP00000091805 | Glycoprotein endo-alpha-1,2-mannosidase. | Family with sequence similarity 217, member B. | 0.489 |
Nck1 | Fam217b | ENSMUSP00000112221 | ENSMUSP00000091805 | Cytoplasmic protein NCK1; Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA (By similarity). | Family with sequence similarity 217, member B. | 0.476 |