node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Anapc16 | Ttc9c | ENSMUSP00000020307 | ENSMUSP00000094513 | Anaphase-promoting complex subunit 16; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC16 family. | Tetratricopeptide repeat protein 9C; Belongs to the TTC9 family. | 0.516 |
Anapc16 | Zmynd12 | ENSMUSP00000020307 | ENSMUSP00000092414 | Anaphase-promoting complex subunit 16; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC16 family. | Zinc finger, MYND domain-containing 12. | 0.587 |
Cacybp | Zmynd12 | ENSMUSP00000014370 | ENSMUSP00000092414 | Calcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). | Zinc finger, MYND domain-containing 12. | 0.588 |
Ciao1 | Fbxl5 | ENSMUSP00000003759 | ENSMUSP00000045792 | Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures AC [...] | F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). | 0.514 |
Ciao1 | Zmynd12 | ENSMUSP00000003759 | ENSMUSP00000092414 | Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures AC [...] | Zinc finger, MYND domain-containing 12. | 0.655 |
Dydc1 | Zmynd12 | ENSMUSP00000139412 | ENSMUSP00000092414 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Zinc finger, MYND domain-containing 12. | 0.686 |
Fam120a | Zmynd12 | ENSMUSP00000053877 | ENSMUSP00000092414 | Constitutive coactivator of PPAR-gamma-like protein 1; Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3- kinase. Binds RNA and promotes the secretion of IGF-II (By similarity). May participate in mRNA transport in the cytoplasm. | Zinc finger, MYND domain-containing 12. | 0.630 |
Fbxl5 | Ciao1 | ENSMUSP00000045792 | ENSMUSP00000003759 | F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). | Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures AC [...] | 0.514 |
Fbxl5 | Zmynd12 | ENSMUSP00000045792 | ENSMUSP00000092414 | F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). | Zinc finger, MYND domain-containing 12. | 0.485 |
Scmh1 | Zmynd12 | ENSMUSP00000101908 | ENSMUSP00000092414 | Polycomb protein SCMH1; Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes; Belongs to the SCM family. | Zinc finger, MYND domain-containing 12. | 0.509 |
Spef2 | Zmynd12 | ENSMUSP00000035762 | ENSMUSP00000092414 | Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation. | Zinc finger, MYND domain-containing 12. | 0.506 |
Ttc9c | Anapc16 | ENSMUSP00000094513 | ENSMUSP00000020307 | Tetratricopeptide repeat protein 9C; Belongs to the TTC9 family. | Anaphase-promoting complex subunit 16; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC16 family. | 0.516 |
Ttc9c | Zmynd12 | ENSMUSP00000094513 | ENSMUSP00000092414 | Tetratricopeptide repeat protein 9C; Belongs to the TTC9 family. | Zinc finger, MYND domain-containing 12. | 0.480 |
Umodl1 | Zmynd12 | ENSMUSP00000110202 | ENSMUSP00000092414 | Uromodulin-like 1. | Zinc finger, MYND domain-containing 12. | 0.520 |
Zmynd12 | Anapc16 | ENSMUSP00000092414 | ENSMUSP00000020307 | Zinc finger, MYND domain-containing 12. | Anaphase-promoting complex subunit 16; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC16 family. | 0.587 |
Zmynd12 | Cacybp | ENSMUSP00000092414 | ENSMUSP00000014370 | Zinc finger, MYND domain-containing 12. | Calcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). | 0.588 |
Zmynd12 | Ciao1 | ENSMUSP00000092414 | ENSMUSP00000003759 | Zinc finger, MYND domain-containing 12. | Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures AC [...] | 0.655 |
Zmynd12 | Dydc1 | ENSMUSP00000092414 | ENSMUSP00000139412 | Zinc finger, MYND domain-containing 12. | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | 0.686 |
Zmynd12 | Fam120a | ENSMUSP00000092414 | ENSMUSP00000053877 | Zinc finger, MYND domain-containing 12. | Constitutive coactivator of PPAR-gamma-like protein 1; Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3- kinase. Binds RNA and promotes the secretion of IGF-II (By similarity). May participate in mRNA transport in the cytoplasm. | 0.630 |
Zmynd12 | Fbxl5 | ENSMUSP00000092414 | ENSMUSP00000045792 | Zinc finger, MYND domain-containing 12. | F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). | 0.485 |