node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actrt1 | Ccin | ENSMUSP00000062570 | ENSMUSP00000092725 | Actin-related protein T1; Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression; Belongs to the actin family. | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | 0.471 |
Ccin | Actrt1 | ENSMUSP00000092725 | ENSMUSP00000062570 | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | Actin-related protein T1; Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression; Belongs to the actin family. | 0.471 |
Ccin | Cylc1 | ENSMUSP00000092725 | ENSMUSP00000098840 | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | Cylicin, basic protein of sperm head cytoskeleton 1. | 0.617 |
Ccin | Cylc2 | ENSMUSP00000092725 | ENSMUSP00000039750 | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | Cylicin, basic protein of sperm head cytoskeleton 2. | 0.873 |
Ccin | Dpy19l2 | ENSMUSP00000092725 | ENSMUSP00000132092 | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | Probable C-mannosyltransferase DPY19L2; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation (By similarity). | 0.504 |
Ccin | Gopc | ENSMUSP00000092725 | ENSMUSP00000020008 | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. | 0.472 |
Ccin | Ropn1 | ENSMUSP00000092725 | ENSMUSP00000023530 | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | Ropporin-1; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. | 0.408 |
Ccin | Spata16 | ENSMUSP00000092725 | ENSMUSP00000043378 | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. Belongs to the SPATA16 family. | 0.524 |
Ccin | Spata19 | ENSMUSP00000092725 | ENSMUSP00000034473 | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis. | 0.483 |
Ccin | Vps54 | ENSMUSP00000092725 | ENSMUSP00000006221 | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling. | 0.500 |
Ccin | Zpbp | ENSMUSP00000092725 | ENSMUSP00000020413 | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | Zona pellucida-binding protein 1; Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization. Belongs to the zona pellucida-binding protein Sp38 family. | 0.469 |
Cylc1 | Ccin | ENSMUSP00000098840 | ENSMUSP00000092725 | Cylicin, basic protein of sperm head cytoskeleton 1. | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | 0.617 |
Cylc1 | Cylc2 | ENSMUSP00000098840 | ENSMUSP00000039750 | Cylicin, basic protein of sperm head cytoskeleton 1. | Cylicin, basic protein of sperm head cytoskeleton 2. | 0.669 |
Cylc2 | Ccin | ENSMUSP00000039750 | ENSMUSP00000092725 | Cylicin, basic protein of sperm head cytoskeleton 2. | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | 0.873 |
Cylc2 | Cylc1 | ENSMUSP00000039750 | ENSMUSP00000098840 | Cylicin, basic protein of sperm head cytoskeleton 2. | Cylicin, basic protein of sperm head cytoskeleton 1. | 0.669 |
Dpy19l2 | Ccin | ENSMUSP00000132092 | ENSMUSP00000092725 | Probable C-mannosyltransferase DPY19L2; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation (By similarity). | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation. | 0.504 |
Dpy19l2 | Gopc | ENSMUSP00000132092 | ENSMUSP00000020008 | Probable C-mannosyltransferase DPY19L2; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation (By similarity). | Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. | 0.712 |
Dpy19l2 | Spata16 | ENSMUSP00000132092 | ENSMUSP00000043378 | Probable C-mannosyltransferase DPY19L2; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation (By similarity). | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. Belongs to the SPATA16 family. | 0.881 |
Dpy19l2 | Vps54 | ENSMUSP00000132092 | ENSMUSP00000006221 | Probable C-mannosyltransferase DPY19L2; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation (By similarity). | Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling. | 0.570 |
Dpy19l2 | Zpbp | ENSMUSP00000132092 | ENSMUSP00000020413 | Probable C-mannosyltransferase DPY19L2; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation (By similarity). | Zona pellucida-binding protein 1; Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization. Belongs to the zona pellucida-binding protein Sp38 family. | 0.816 |