node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cog4 | Cog8 | ENSMUSP00000034203 | ENSMUSP00000093173 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.997 |
Cog4 | Gcc1 | ENSMUSP00000034203 | ENSMUSP00000087997 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure. | 0.669 |
Cog4 | Gcc2 | ENSMUSP00000034203 | ENSMUSP00000054033 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity). | 0.560 |
Cog4 | Golga1 | ENSMUSP00000034203 | ENSMUSP00000037735 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | Golgin subfamily A member 1; Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. | 0.669 |
Cog4 | Rab6a | ENSMUSP00000034203 | ENSMUSP00000032946 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | Ras-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.721 |
Cog4 | Rab6b | ENSMUSP00000034203 | ENSMUSP00000035155 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | Ras-related protein Rab-6B; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.570 |
Cog4 | Tmf1 | ENSMUSP00000034203 | ENSMUSP00000093325 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | TATA element modulatory factor; Potential coactivator of the androgen receptor. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER (By similarity). Mediates STAT3 degradation. | 0.636 |
Cog4 | Uso1 | ENSMUSP00000034203 | ENSMUSP00000031355 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | General vesicular transport factor p115; General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity; Belongs to the VDP/USO1/EDE1 family. | 0.405 |
Cog4 | Vps52 | ENSMUSP00000034203 | ENSMUSP00000025178 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] | 0.828 |
Cog4 | Vps54 | ENSMUSP00000034203 | ENSMUSP00000006221 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling. | 0.884 |
Cog8 | Cog4 | ENSMUSP00000093173 | ENSMUSP00000034203 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. | 0.997 |
Cog8 | Gcc1 | ENSMUSP00000093173 | ENSMUSP00000087997 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure. | 0.551 |
Cog8 | Gcc2 | ENSMUSP00000093173 | ENSMUSP00000054033 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity). | 0.559 |
Cog8 | Golga1 | ENSMUSP00000093173 | ENSMUSP00000037735 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Golgin subfamily A member 1; Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. | 0.685 |
Cog8 | Rab6a | ENSMUSP00000093173 | ENSMUSP00000032946 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Ras-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.792 |
Cog8 | Rab6b | ENSMUSP00000093173 | ENSMUSP00000035155 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Ras-related protein Rab-6B; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.724 |
Cog8 | Tmf1 | ENSMUSP00000093173 | ENSMUSP00000093325 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | TATA element modulatory factor; Potential coactivator of the androgen receptor. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER (By similarity). Mediates STAT3 degradation. | 0.645 |
Cog8 | Uso1 | ENSMUSP00000093173 | ENSMUSP00000031355 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | General vesicular transport factor p115; General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity; Belongs to the VDP/USO1/EDE1 family. | 0.454 |
Cog8 | Vps52 | ENSMUSP00000093173 | ENSMUSP00000025178 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] | 0.893 |
Cog8 | Vps54 | ENSMUSP00000093173 | ENSMUSP00000006221 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling. | 0.878 |