node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bmper | Moxd1 | ENSMUSP00000071872 | ENSMUSP00000093460 | BMP-binding endothelial regulator protein; Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | 0.549 |
Cd163 | Hmox1 | ENSMUSP00000108160 | ENSMUSP00000005548 | Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. | 0.587 |
Cd163 | Moxd1 | ENSMUSP00000108160 | ENSMUSP00000093460 | Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | 0.430 |
Cd163 | Pf4 | ENSMUSP00000108160 | ENSMUSP00000031320 | Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] | Platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation (By similarity). | 0.444 |
Cplx3 | Moxd1 | ENSMUSP00000046748 | ENSMUSP00000093460 | Complexin-3; Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion. Required for the maintenance of synaptic ultrastructure in the adult retina. Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina. Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release. | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | 0.555 |
Ddc | Moxd1 | ENSMUSP00000136467 | ENSMUSP00000093460 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | 0.606 |
Ddc | Pnmt | ENSMUSP00000136467 | ENSMUSP00000035549 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. | Phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. | 0.713 |
Foxa1 | Moxd1 | ENSMUSP00000041118 | ENSMUSP00000093460 | Hepatocyte nuclear factor 3-alpha; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures [...] | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | 0.470 |
Hmox1 | Cd163 | ENSMUSP00000005548 | ENSMUSP00000108160 | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. | Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] | 0.587 |
Hmox1 | Moxd1 | ENSMUSP00000005548 | ENSMUSP00000093460 | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | 0.456 |
Hmox1 | Srxn1 | ENSMUSP00000005548 | ENSMUSP00000046196 | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. Belongs to the sulfiredoxin family. | 0.694 |
Lum | Moxd1 | ENSMUSP00000040877 | ENSMUSP00000093460 | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | 0.416 |
Moxd1 | Bmper | ENSMUSP00000093460 | ENSMUSP00000071872 | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | BMP-binding endothelial regulator protein; Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. | 0.549 |
Moxd1 | Cd163 | ENSMUSP00000093460 | ENSMUSP00000108160 | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] | 0.430 |
Moxd1 | Cplx3 | ENSMUSP00000093460 | ENSMUSP00000046748 | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | Complexin-3; Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion. Required for the maintenance of synaptic ultrastructure in the adult retina. Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina. Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release. | 0.555 |
Moxd1 | Ddc | ENSMUSP00000093460 | ENSMUSP00000136467 | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. | 0.606 |
Moxd1 | Foxa1 | ENSMUSP00000093460 | ENSMUSP00000041118 | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | Hepatocyte nuclear factor 3-alpha; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures [...] | 0.470 |
Moxd1 | Hmox1 | ENSMUSP00000093460 | ENSMUSP00000005548 | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. | 0.456 |
Moxd1 | Lum | ENSMUSP00000093460 | ENSMUSP00000040877 | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.416 |
Moxd1 | Pf4 | ENSMUSP00000093460 | ENSMUSP00000031320 | DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family. | Platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation (By similarity). | 0.455 |