node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Clspn | Gprin2 | ENSMUSP00000045344 | ENSMUSP00000154640 | Claspin; Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks (By similarity); Belongs [...] | G protein-regulated inducer of neurite outgrowth 2. | 0.533 |
Dclk3 | Gprin2 | ENSMUSP00000107510 | ENSMUSP00000154640 | Serine/threonine-protein kinase DCLK3. | G protein-regulated inducer of neurite outgrowth 2. | 0.627 |
Dclk3 | Lynx1 | ENSMUSP00000107510 | ENSMUSP00000023259 | Serine/threonine-protein kinase DCLK3. | Ly-6/neurotoxin-like protein 1; Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and ex [...] | 0.535 |
Gprin2 | Clspn | ENSMUSP00000154640 | ENSMUSP00000045344 | G protein-regulated inducer of neurite outgrowth 2. | Claspin; Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks (By similarity); Belongs [...] | 0.533 |
Gprin2 | Dclk3 | ENSMUSP00000154640 | ENSMUSP00000107510 | G protein-regulated inducer of neurite outgrowth 2. | Serine/threonine-protein kinase DCLK3. | 0.627 |
Gprin2 | Htr4 | ENSMUSP00000154640 | ENSMUSP00000027560 | G protein-regulated inducer of neurite outgrowth 2. | 5-hydroxytryptamine receptor 4; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (By similarity). | 0.546 |
Gprin2 | Hydin | ENSMUSP00000154640 | ENSMUSP00000046204 | G protein-regulated inducer of neurite outgrowth 2. | Hydrocephalus-inducing protein; Required for ciliary motility. | 0.548 |
Gprin2 | Inmt | ENSMUSP00000154640 | ENSMUSP00000003569 | G protein-regulated inducer of neurite outgrowth 2. | Indolethylamine N-methyltransferase; Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as thioether S- methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3- methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2- methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNM [...] | 0.528 |
Gprin2 | Lynx1 | ENSMUSP00000154640 | ENSMUSP00000023259 | G protein-regulated inducer of neurite outgrowth 2. | Ly-6/neurotoxin-like protein 1; Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and ex [...] | 0.545 |
Gprin2 | Npy4r | ENSMUSP00000154640 | ENSMUSP00000056576 | G protein-regulated inducer of neurite outgrowth 2. | Neuropeptide Y receptor type 4; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP >> PYY >= NPY. | 0.640 |
Gprin2 | Orai1 | ENSMUSP00000154640 | ENSMUSP00000113097 | G protein-regulated inducer of neurite outgrowth 2. | Calcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT; Belongs to the Orai family. | 0.495 |
Gprin2 | Pigc | ENSMUSP00000154640 | ENSMUSP00000141646 | G protein-regulated inducer of neurite outgrowth 2. | Phosphatidylinositol N-acetylglucosaminyltransferase subunit C; Involved in GPI anchor biosynthesis. Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N- acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. | 0.519 |
Gprin2 | Syt15 | ENSMUSP00000154640 | ENSMUSP00000036755 | G protein-regulated inducer of neurite outgrowth 2. | Synaptotagmin-15; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues; Belongs to the synaptotagmin family. | 0.607 |
Htr4 | Gprin2 | ENSMUSP00000027560 | ENSMUSP00000154640 | 5-hydroxytryptamine receptor 4; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (By similarity). | G protein-regulated inducer of neurite outgrowth 2. | 0.546 |
Hydin | Gprin2 | ENSMUSP00000046204 | ENSMUSP00000154640 | Hydrocephalus-inducing protein; Required for ciliary motility. | G protein-regulated inducer of neurite outgrowth 2. | 0.548 |
Inmt | Gprin2 | ENSMUSP00000003569 | ENSMUSP00000154640 | Indolethylamine N-methyltransferase; Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as thioether S- methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3- methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2- methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNM [...] | G protein-regulated inducer of neurite outgrowth 2. | 0.528 |
Lynx1 | Dclk3 | ENSMUSP00000023259 | ENSMUSP00000107510 | Ly-6/neurotoxin-like protein 1; Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and ex [...] | Serine/threonine-protein kinase DCLK3. | 0.535 |
Lynx1 | Gprin2 | ENSMUSP00000023259 | ENSMUSP00000154640 | Ly-6/neurotoxin-like protein 1; Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and ex [...] | G protein-regulated inducer of neurite outgrowth 2. | 0.545 |
Npy4r | Gprin2 | ENSMUSP00000056576 | ENSMUSP00000154640 | Neuropeptide Y receptor type 4; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP >> PYY >= NPY. | G protein-regulated inducer of neurite outgrowth 2. | 0.640 |
Npy4r | Syt15 | ENSMUSP00000056576 | ENSMUSP00000036755 | Neuropeptide Y receptor type 4; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP >> PYY >= NPY. | Synaptotagmin-15; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues; Belongs to the synaptotagmin family. | 0.440 |