STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Scrt1Transcriptional repressor scratch 1; Transcriptional repressor that binds E-box motif CAGGTG (By similarity). Appears to function downstream of proneural bHLH proteins in promoting neural differentiation. (348 aa)    
Predicted Functional Partners:
Trmt10b
tRNA methyltransferase 10 homolog B; S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs. Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
      
 0.539
Olfr530
Olfactory receptor MOR252-2.
      
 0.538
Gad1
Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family.
   
  
 0.476
Tmem144
Transmembrane protein 144.
      
 0.474
Prrg4
Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity).
      
 0.472
Slc17a6
Vesicular glutamate transporter 2; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
   
  
 0.456
Gad2
Glutamate decarboxylase 2; Catalyzes the production of GABA.
   
  
 0.454
Cep41
Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium.
      
 0.439
Gata3
Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.
    
 
 0.411
Slc32a1
Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles.
   
  
 0.410
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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