node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc47 | Emc3 | ENSMUSP00000002043 | ENSMUSP00000032425 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | ER membrane protein complex subunit 3; Belongs to the EMC3 family. | 0.622 |
Ccdc47 | Ncln | ENSMUSP00000002043 | ENSMUSP00000020463 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | 0.905 |
Ccdc47 | Rab5if | ENSMUSP00000002043 | ENSMUSP00000029165 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | Respirasome Complex Assembly Factor 1; Acts as an assembly factor for mitochondrial respiratory complexes. | 0.554 |
Ccdc47 | Rpl37a | ENSMUSP00000002043 | ENSMUSP00000058919 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | 60S ribosomal protein L37a; Belongs to the eukaryotic ribosomal protein eL43 family. | 0.665 |
Ccdc47 | Sec61a2 | ENSMUSP00000002043 | ENSMUSP00000100046 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | Protein transport protein Sec61 subunit alpha isoform 2; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). | 0.776 |
Ccdc47 | Sec61g | ENSMUSP00000002043 | ENSMUSP00000132348 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | Protein transport protein Sec61 subunit gamma; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). | 0.725 |
Ccdc47 | Tmco1 | ENSMUSP00000002043 | ENSMUSP00000142042 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store ; Belongs to the TMCO1 family. | 0.953 |
Ccdc47 | Tmem147 | ENSMUSP00000002043 | ENSMUSP00000006478 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (By similarity). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (By similarity). | 0.908 |
Emc3 | Ccdc47 | ENSMUSP00000032425 | ENSMUSP00000002043 | ER membrane protein complex subunit 3; Belongs to the EMC3 family. | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | 0.622 |
Emc3 | Sec61a2 | ENSMUSP00000032425 | ENSMUSP00000100046 | ER membrane protein complex subunit 3; Belongs to the EMC3 family. | Protein transport protein Sec61 subunit alpha isoform 2; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). | 0.438 |
Emc3 | Tmco1 | ENSMUSP00000032425 | ENSMUSP00000142042 | ER membrane protein complex subunit 3; Belongs to the EMC3 family. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store ; Belongs to the TMCO1 family. | 0.782 |
Emc3 | Tmem147 | ENSMUSP00000032425 | ENSMUSP00000006478 | ER membrane protein complex subunit 3; Belongs to the EMC3 family. | Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (By similarity). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (By similarity). | 0.543 |
Farsb | Sec61a2 | ENSMUSP00000129828 | ENSMUSP00000100046 | Phenylalanine--tRNA ligase beta subunit. | Protein transport protein Sec61 subunit alpha isoform 2; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). | 0.411 |
Farsb | Tmco1 | ENSMUSP00000129828 | ENSMUSP00000142042 | Phenylalanine--tRNA ligase beta subunit. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store ; Belongs to the TMCO1 family. | 0.899 |
Gas7 | Tmco1 | ENSMUSP00000104322 | ENSMUSP00000142042 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store ; Belongs to the TMCO1 family. | 0.707 |
Ncln | Ccdc47 | ENSMUSP00000020463 | ENSMUSP00000002043 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | 0.905 |
Ncln | Rab5if | ENSMUSP00000020463 | ENSMUSP00000029165 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | Respirasome Complex Assembly Factor 1; Acts as an assembly factor for mitochondrial respiratory complexes. | 0.572 |
Ncln | Rpl37a | ENSMUSP00000020463 | ENSMUSP00000058919 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | 60S ribosomal protein L37a; Belongs to the eukaryotic ribosomal protein eL43 family. | 0.668 |
Ncln | Sec61a2 | ENSMUSP00000020463 | ENSMUSP00000100046 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | Protein transport protein Sec61 subunit alpha isoform 2; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). | 0.771 |
Ncln | Sec61g | ENSMUSP00000020463 | ENSMUSP00000132348 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | Protein transport protein Sec61 subunit gamma; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). | 0.665 |