node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AW554918 | Adamtsl3 | ENSMUSP00000095248 | ENSMUSP00000133637 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | ADAMTS-like 3. | 0.935 |
AW554918 | Bloc1s6 | ENSMUSP00000095248 | ENSMUSP00000005954 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | 0.579 |
AW554918 | Ccdc138 | ENSMUSP00000095248 | ENSMUSP00000043040 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | Coiled-coil domain-containing protein 138. | 0.482 |
AW554918 | Frk | ENSMUSP00000095248 | ENSMUSP00000019913 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | Tyrosine-protein kinase FRK; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity). | 0.722 |
AW554918 | Krtap24-1 | ENSMUSP00000095248 | ENSMUSP00000052005 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | Keratin-associated protein 24-1. | 0.566 |
AW554918 | Mipol1 | ENSMUSP00000095248 | ENSMUSP00000121617 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | Mirror-image polydactyly gene 1 protein homolog. | 0.938 |
AW554918 | Rpap2 | ENSMUSP00000095248 | ENSMUSP00000070209 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | Putative RNA polymerase II subunit B1 CTD phosphatase Rpap2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes; Belongs to the RPAP2 family. | 0.941 |
AW554918 | Spata32 | ENSMUSP00000095248 | ENSMUSP00000099365 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | Spermatogenesis-associated protein 32. | 0.559 |
AW554918 | Tpgs2 | ENSMUSP00000095248 | ENSMUSP00000111484 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | Tubulin polyglutamylase complex subunit 2. | 0.692 |
AW554918 | Wdpcp | ENSMUSP00000095248 | ENSMUSP00000020568 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | WD repeat-containing and planar cell polarity effector protein fritz homolog; Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. | 0.618 |
Adamtsl3 | AW554918 | ENSMUSP00000133637 | ENSMUSP00000095248 | ADAMTS-like 3. | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | 0.935 |
Adamtsl3 | Frk | ENSMUSP00000133637 | ENSMUSP00000019913 | ADAMTS-like 3. | Tyrosine-protein kinase FRK; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity). | 0.604 |
Adamtsl3 | Mipol1 | ENSMUSP00000133637 | ENSMUSP00000121617 | ADAMTS-like 3. | Mirror-image polydactyly gene 1 protein homolog. | 0.935 |
Adamtsl3 | Wdpcp | ENSMUSP00000133637 | ENSMUSP00000020568 | ADAMTS-like 3. | WD repeat-containing and planar cell polarity effector protein fritz homolog; Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. | 0.561 |
Bloc1s6 | AW554918 | ENSMUSP00000005954 | ENSMUSP00000095248 | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | 0.579 |
Bloc1s6 | Mipol1 | ENSMUSP00000005954 | ENSMUSP00000121617 | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | Mirror-image polydactyly gene 1 protein homolog. | 0.935 |
Bloc1s6 | Rpap2 | ENSMUSP00000005954 | ENSMUSP00000070209 | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | Putative RNA polymerase II subunit B1 CTD phosphatase Rpap2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes; Belongs to the RPAP2 family. | 0.587 |
Ccdc138 | AW554918 | ENSMUSP00000043040 | ENSMUSP00000095248 | Coiled-coil domain-containing protein 138. | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | 0.482 |
Frk | AW554918 | ENSMUSP00000019913 | ENSMUSP00000095248 | Tyrosine-protein kinase FRK; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity). | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | 0.722 |
Frk | Adamtsl3 | ENSMUSP00000019913 | ENSMUSP00000133637 | Tyrosine-protein kinase FRK; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity). | ADAMTS-like 3. | 0.604 |