node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
4833427G06Rik | Btaf1 | ENSMUSP00000126725 | ENSMUSP00000097093 | UPF0722 protein C11orf88 homolog; Belongs to the UPF0722 family. | B-TFIID TATA-box-binding protein-associated factor 1. | 0.755 |
4833427G06Rik | Dr1 | ENSMUSP00000126725 | ENSMUSP00000031190 | UPF0722 protein C11orf88 homolog; Belongs to the UPF0722 family. | Protein Dr1; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity); Belongs to the NC2 beta/DR1 family. | 0.703 |
4833427G06Rik | Drap1 | ENSMUSP00000126725 | ENSMUSP00000109304 | UPF0722 protein C11orf88 homolog; Belongs to the UPF0722 family. | Dr1-associated corepressor; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity). Belongs to the NC2 alpha/DRAP1 family. | 0.738 |
4833427G06Rik | Supt3 | ENSMUSP00000126725 | ENSMUSP00000050783 | UPF0722 protein C11orf88 homolog; Belongs to the UPF0722 family. | SPT3, SAGA and STAGA complex component. | 0.728 |
4833427G06Rik | Taf1 | ENSMUSP00000126725 | ENSMUSP00000114765 | UPF0722 protein C11orf88 homolog; Belongs to the UPF0722 family. | Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. Belongs to the TAF1 family. | 0.755 |
4833427G06Rik | Taf2 | ENSMUSP00000126725 | ENSMUSP00000043733 | UPF0722 protein C11orf88 homolog; Belongs to the UPF0722 family. | Transcription initiation factor TFIID subunit 2; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter (By similarity). | 0.755 |
Btaf1 | 4833427G06Rik | ENSMUSP00000097093 | ENSMUSP00000126725 | B-TFIID TATA-box-binding protein-associated factor 1. | UPF0722 protein C11orf88 homolog; Belongs to the UPF0722 family. | 0.755 |
Btaf1 | Dr1 | ENSMUSP00000097093 | ENSMUSP00000031190 | B-TFIID TATA-box-binding protein-associated factor 1. | Protein Dr1; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity); Belongs to the NC2 beta/DR1 family. | 0.891 |
Btaf1 | Drap1 | ENSMUSP00000097093 | ENSMUSP00000109304 | B-TFIID TATA-box-binding protein-associated factor 1. | Dr1-associated corepressor; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity). Belongs to the NC2 alpha/DRAP1 family. | 0.938 |
Btaf1 | Ranbp2 | ENSMUSP00000097093 | ENSMUSP00000003310 | B-TFIID TATA-box-binding protein-associated factor 1. | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1 (By similarity). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuc [...] | 0.669 |
Btaf1 | Supt3 | ENSMUSP00000097093 | ENSMUSP00000050783 | B-TFIID TATA-box-binding protein-associated factor 1. | SPT3, SAGA and STAGA complex component. | 0.650 |
Btaf1 | Taf1 | ENSMUSP00000097093 | ENSMUSP00000114765 | B-TFIID TATA-box-binding protein-associated factor 1. | Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. Belongs to the TAF1 family. | 0.699 |
Btaf1 | Taf2 | ENSMUSP00000097093 | ENSMUSP00000043733 | B-TFIID TATA-box-binding protein-associated factor 1. | Transcription initiation factor TFIID subunit 2; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter (By similarity). | 0.768 |
Btaf1 | Tbp | ENSMUSP00000097093 | ENSMUSP00000124317 | B-TFIID TATA-box-binding protein-associated factor 1. | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase [...] | 0.960 |
Btaf1 | Tbpl1 | ENSMUSP00000097093 | ENSMUSP00000114223 | B-TFIID TATA-box-binding protein-associated factor 1. | TATA box-binding protein-like protein 1; Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes (By similarity). Seems to also mediate the transcription of NF1. Does not bind the TATA box. | 0.805 |
Btaf1 | Tbpl2 | ENSMUSP00000097093 | ENSMUSP00000079309 | B-TFIID TATA-box-binding protein-associated factor 1. | TATA box-binding protein-like protein 2; Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. | 0.916 |
Dr1 | 4833427G06Rik | ENSMUSP00000031190 | ENSMUSP00000126725 | Protein Dr1; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity); Belongs to the NC2 beta/DR1 family. | UPF0722 protein C11orf88 homolog; Belongs to the UPF0722 family. | 0.703 |
Dr1 | Btaf1 | ENSMUSP00000031190 | ENSMUSP00000097093 | Protein Dr1; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity); Belongs to the NC2 beta/DR1 family. | B-TFIID TATA-box-binding protein-associated factor 1. | 0.891 |
Dr1 | Drap1 | ENSMUSP00000031190 | ENSMUSP00000109304 | Protein Dr1; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity); Belongs to the NC2 beta/DR1 family. | Dr1-associated corepressor; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity). Belongs to the NC2 alpha/DRAP1 family. | 0.998 |
Dr1 | Supt3 | ENSMUSP00000031190 | ENSMUSP00000050783 | Protein Dr1; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity); Belongs to the NC2 beta/DR1 family. | SPT3, SAGA and STAGA complex component. | 0.774 |