STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cfap44Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function; Belongs to the CFAP44 family. (1843 aa)    
Predicted Functional Partners:
Qrich2
Glutamine-rich protein 2; Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility.
    
 
 0.835
Cfap69
Cilia- and flagella-associated protein 69; Cilium- and flagellum-associated protein. In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways. Required for sperm flagellum assembly and stability.
   
  
 0.829
Cfap70
Cilia and flagella-associated protein 70.
   
 
 0.773
Dnah1
Dynein heavy chain 1, axonemal; Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (By similarity).
   
  
 0.765
Ttc21a
Tetratricopeptide repeat protein 21A; Intraflagellar transport (IFT)-associated protein required for spermatogenesis. Required for sperm flagellar formation and intraflagellar transport. Belongs to the TTC21 family.
   
 
 0.756
Fsip2
Fibrous sheath-interacting protein 2; Plays a role in spermatogenesis.
    
 
 0.725
Cfap43
Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function; Belongs to the CFAP43 family.
   
  
0.720
Ttc29
Tetratricopeptide repeat protein 29.
   
  
 0.713
Cfap65
Cilia- and flagella-associated protein 65; May play a role in sperm motility. Belongs to the CFAP65 family.
   
 
 0.703
Armc2
Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function. Involved in axonemal central pair complex assembly and/or stability.
   
 
 0.703
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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