node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fam118a | Letm2 | ENSMUSP00000154985 | ENSMUSP00000078160 | Protein FAM118A; Belongs to the FAM118 family. | LETM1 domain-containing protein LETM2, mitochondrial. | 0.651 |
Fam118a | Pld6 | ENSMUSP00000154985 | ENSMUSP00000115503 | Protein FAM118A; Belongs to the FAM118 family. | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | 0.545 |
Fam118a | Reep6 | ENSMUSP00000154985 | ENSMUSP00000100991 | Protein FAM118A; Belongs to the FAM118 family. | Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane. | 0.544 |
Fam118a | Rhbdd3 | ENSMUSP00000154985 | ENSMUSP00000099131 | Protein FAM118A; Belongs to the FAM118 family. | Rhomboid domain-containing protein 3. | 0.671 |
Fam118a | Tmem39b | ENSMUSP00000154985 | ENSMUSP00000099648 | Protein FAM118A; Belongs to the FAM118 family. | Transmembrane protein 39B. | 0.664 |
Lcn12 | Rhbdd3 | ENSMUSP00000028312 | ENSMUSP00000099131 | Epididymal-specific lipocalin-12; Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity); Belongs to the calycin superfamily. Lipocalin family. | Rhomboid domain-containing protein 3. | 0.591 |
Letm2 | Fam118a | ENSMUSP00000078160 | ENSMUSP00000154985 | LETM1 domain-containing protein LETM2, mitochondrial. | Protein FAM118A; Belongs to the FAM118 family. | 0.651 |
Letm2 | Pld6 | ENSMUSP00000078160 | ENSMUSP00000115503 | LETM1 domain-containing protein LETM2, mitochondrial. | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | 0.523 |
Letm2 | Reep6 | ENSMUSP00000078160 | ENSMUSP00000100991 | LETM1 domain-containing protein LETM2, mitochondrial. | Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane. | 0.500 |
Letm2 | Rhbdd3 | ENSMUSP00000078160 | ENSMUSP00000099131 | LETM1 domain-containing protein LETM2, mitochondrial. | Rhomboid domain-containing protein 3. | 0.604 |
Letm2 | Tmem39b | ENSMUSP00000078160 | ENSMUSP00000099648 | LETM1 domain-containing protein LETM2, mitochondrial. | Transmembrane protein 39B. | 0.536 |
Pld6 | Fam118a | ENSMUSP00000115503 | ENSMUSP00000154985 | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | Protein FAM118A; Belongs to the FAM118 family. | 0.545 |
Pld6 | Letm2 | ENSMUSP00000115503 | ENSMUSP00000078160 | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | LETM1 domain-containing protein LETM2, mitochondrial. | 0.523 |
Pld6 | Reep6 | ENSMUSP00000115503 | ENSMUSP00000100991 | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane. | 0.400 |
Pld6 | Rhbdd3 | ENSMUSP00000115503 | ENSMUSP00000099131 | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | Rhomboid domain-containing protein 3. | 0.584 |
Pld6 | Tmem39b | ENSMUSP00000115503 | ENSMUSP00000099648 | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | Transmembrane protein 39B. | 0.449 |
Reep6 | Fam118a | ENSMUSP00000100991 | ENSMUSP00000154985 | Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane. | Protein FAM118A; Belongs to the FAM118 family. | 0.544 |
Reep6 | Letm2 | ENSMUSP00000100991 | ENSMUSP00000078160 | Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane. | LETM1 domain-containing protein LETM2, mitochondrial. | 0.500 |
Reep6 | Pld6 | ENSMUSP00000100991 | ENSMUSP00000115503 | Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane. | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | 0.400 |
Reep6 | Rhbdd3 | ENSMUSP00000100991 | ENSMUSP00000099131 | Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane. | Rhomboid domain-containing protein 3. | 0.593 |