node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gnl2 | Gtpbp4 | ENSMUSP00000030684 | ENSMUSP00000152412 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity). | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 0.999 |
Gnl2 | Mdn1 | ENSMUSP00000030684 | ENSMUSP00000136222 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity). | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. | 0.902 |
Gnl2 | Mrto4 | ENSMUSP00000030684 | ENSMUSP00000099561 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity). | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. | 0.982 |
Gnl2 | Nle1 | ENSMUSP00000030684 | ENSMUSP00000099502 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity). | Notchless protein homolog 1; Plays a role in regulating Notch activity (Probable). Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival. | 0.970 |
Gnl2 | Nop53 | ENSMUSP00000030684 | ENSMUSP00000043981 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity). | Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription (By similarity). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and all [...] | 0.995 |
Gnl2 | Nsa2 | ENSMUSP00000030684 | ENSMUSP00000073161 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity). | Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). | 0.997 |
Gnl2 | Pa2g4 | ENSMUSP00000030684 | ENSMUSP00000114434 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity). | Proliferation-associated protein 2G4; May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1- regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved [...] | 0.984 |
Gnl2 | Rpf2 | ENSMUSP00000030684 | ENSMUSP00000138581 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity). | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family. | 0.993 |
Gnl2 | Sdad1 | ENSMUSP00000030684 | ENSMUSP00000031364 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity). | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm. | 0.985 |
Gnl2 | Wdr18 | ENSMUSP00000030684 | ENSMUSP00000041049 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity). | WD repeat-containing protein 18; May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes; Belongs to the WD repeat IPI3/WDR18 family. | 0.983 |
Gtpbp4 | Gnl2 | ENSMUSP00000152412 | ENSMUSP00000030684 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity). | 0.999 |
Gtpbp4 | Mdn1 | ENSMUSP00000152412 | ENSMUSP00000136222 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. | 0.851 |
Gtpbp4 | Mrto4 | ENSMUSP00000152412 | ENSMUSP00000099561 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. | 0.999 |
Gtpbp4 | Nle1 | ENSMUSP00000152412 | ENSMUSP00000099502 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Notchless protein homolog 1; Plays a role in regulating Notch activity (Probable). Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival. | 0.980 |
Gtpbp4 | Nop53 | ENSMUSP00000152412 | ENSMUSP00000043981 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription (By similarity). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and all [...] | 0.998 |
Gtpbp4 | Nsa2 | ENSMUSP00000152412 | ENSMUSP00000073161 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). | 0.999 |
Gtpbp4 | Pa2g4 | ENSMUSP00000152412 | ENSMUSP00000114434 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Proliferation-associated protein 2G4; May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1- regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved [...] | 0.990 |
Gtpbp4 | Rpf2 | ENSMUSP00000152412 | ENSMUSP00000138581 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family. | 0.998 |
Gtpbp4 | Sdad1 | ENSMUSP00000152412 | ENSMUSP00000031364 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm. | 0.994 |
Gtpbp4 | Wdr18 | ENSMUSP00000152412 | ENSMUSP00000041049 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | WD repeat-containing protein 18; May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes; Belongs to the WD repeat IPI3/WDR18 family. | 0.928 |