node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pex10 | Pex11b | ENSMUSP00000099469 | ENSMUSP00000113365 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family. | 0.861 |
Pex10 | Pex12 | ENSMUSP00000099469 | ENSMUSP00000018877 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | 0.999 |
Pex10 | Pex13 | ENSMUSP00000099469 | ENSMUSP00000020523 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity). | 0.987 |
Pex10 | Pex14 | ENSMUSP00000099469 | ENSMUSP00000099506 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin. | 0.952 |
Pex10 | Pex19 | ENSMUSP00000099469 | ENSMUSP00000075289 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. | 0.982 |
Pex10 | Pex2 | ENSMUSP00000099469 | ENSMUSP00000129311 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family. | 0.974 |
Pex10 | Pex5 | ENSMUSP00000099469 | ENSMUSP00000108151 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.972 |
Pex10 | Pex5l | ENSMUSP00000099469 | ENSMUSP00000142196 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence. Belongs to the peroxisomal targeting signal receptor family. | 0.896 |
Pex10 | Pex6 | ENSMUSP00000099469 | ENSMUSP00000002840 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Probably required for protein import into peroxisomes. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (By similarity). | 0.968 |
Pex10 | Pex7 | ENSMUSP00000099469 | ENSMUSP00000020182 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import. | 0.966 |
Pex11b | Pex10 | ENSMUSP00000113365 | ENSMUSP00000099469 | Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family. | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. | 0.861 |
Pex11b | Pex12 | ENSMUSP00000113365 | ENSMUSP00000018877 | Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family. | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | 0.935 |
Pex11b | Pex13 | ENSMUSP00000113365 | ENSMUSP00000020523 | Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family. | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity). | 0.959 |
Pex11b | Pex14 | ENSMUSP00000113365 | ENSMUSP00000099506 | Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family. | Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin. | 0.934 |
Pex11b | Pex19 | ENSMUSP00000113365 | ENSMUSP00000075289 | Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family. | Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. | 0.985 |
Pex11b | Pex2 | ENSMUSP00000113365 | ENSMUSP00000129311 | Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family. | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family. | 0.814 |
Pex11b | Pex5 | ENSMUSP00000113365 | ENSMUSP00000108151 | Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family. | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.834 |
Pex11b | Pex5l | ENSMUSP00000113365 | ENSMUSP00000142196 | Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family. | PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence. Belongs to the peroxisomal targeting signal receptor family. | 0.624 |
Pex11b | Pex6 | ENSMUSP00000113365 | ENSMUSP00000002840 | Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family. | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Probably required for protein import into peroxisomes. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (By similarity). | 0.833 |
Pex11b | Pex7 | ENSMUSP00000113365 | ENSMUSP00000020182 | Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family. | Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import. | 0.854 |