node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mdm2 | Rpl11 | ENSMUSP00000020408 | ENSMUSP00000099595 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73- mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain (By similarity). Also acts as a ubiquitin ligase E3 toward itself, ARRB1 and ARBB2. Permits the nuclear export of p53/TP53 (By similarity). Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein (By similarity). Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and [...] | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.999 |
Mrpl21 | Mrpl27 | ENSMUSP00000025745 | ENSMUSP00000025278 | 39S ribosomal protein L21, mitochondrial. | 39S ribosomal protein L27, mitochondrial; Belongs to the bacterial ribosomal protein bL27 family. | 0.999 |
Mrpl21 | Mrpl36 | ENSMUSP00000025745 | ENSMUSP00000022098 | 39S ribosomal protein L21, mitochondrial. | 39S ribosomal protein L36, mitochondrial; Belongs to the bacterial ribosomal protein bL36 family. | 0.999 |
Mrpl21 | Rpl11 | ENSMUSP00000025745 | ENSMUSP00000099595 | 39S ribosomal protein L21, mitochondrial. | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.999 |
Mrpl21 | Rps11 | ENSMUSP00000025745 | ENSMUSP00000003521 | 39S ribosomal protein L21, mitochondrial. | 40S ribosomal protein S11. | 0.999 |
Mrpl21 | Rps18 | ENSMUSP00000025745 | ENSMUSP00000008812 | 39S ribosomal protein L21, mitochondrial. | 40S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. | 0.959 |
Mrpl27 | Mrpl21 | ENSMUSP00000025278 | ENSMUSP00000025745 | 39S ribosomal protein L27, mitochondrial; Belongs to the bacterial ribosomal protein bL27 family. | 39S ribosomal protein L21, mitochondrial. | 0.999 |
Mrpl27 | Mrpl36 | ENSMUSP00000025278 | ENSMUSP00000022098 | 39S ribosomal protein L27, mitochondrial; Belongs to the bacterial ribosomal protein bL27 family. | 39S ribosomal protein L36, mitochondrial; Belongs to the bacterial ribosomal protein bL36 family. | 0.998 |
Mrpl27 | Rpl11 | ENSMUSP00000025278 | ENSMUSP00000099595 | 39S ribosomal protein L27, mitochondrial; Belongs to the bacterial ribosomal protein bL27 family. | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.999 |
Mrpl27 | Rps11 | ENSMUSP00000025278 | ENSMUSP00000003521 | 39S ribosomal protein L27, mitochondrial; Belongs to the bacterial ribosomal protein bL27 family. | 40S ribosomal protein S11. | 0.998 |
Mrpl27 | Rps18 | ENSMUSP00000025278 | ENSMUSP00000008812 | 39S ribosomal protein L27, mitochondrial; Belongs to the bacterial ribosomal protein bL27 family. | 40S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. | 0.957 |
Mrpl36 | Mrpl21 | ENSMUSP00000022098 | ENSMUSP00000025745 | 39S ribosomal protein L36, mitochondrial; Belongs to the bacterial ribosomal protein bL36 family. | 39S ribosomal protein L21, mitochondrial. | 0.999 |
Mrpl36 | Mrpl27 | ENSMUSP00000022098 | ENSMUSP00000025278 | 39S ribosomal protein L36, mitochondrial; Belongs to the bacterial ribosomal protein bL36 family. | 39S ribosomal protein L27, mitochondrial; Belongs to the bacterial ribosomal protein bL27 family. | 0.998 |
Mrpl36 | Rpl11 | ENSMUSP00000022098 | ENSMUSP00000099595 | 39S ribosomal protein L36, mitochondrial; Belongs to the bacterial ribosomal protein bL36 family. | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.999 |
Mrpl36 | Rps11 | ENSMUSP00000022098 | ENSMUSP00000003521 | 39S ribosomal protein L36, mitochondrial; Belongs to the bacterial ribosomal protein bL36 family. | 40S ribosomal protein S11. | 0.999 |
Mrpl36 | Rps18 | ENSMUSP00000022098 | ENSMUSP00000008812 | 39S ribosomal protein L36, mitochondrial; Belongs to the bacterial ribosomal protein bL36 family. | 40S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. | 0.961 |
Rack1 | Rpl11 | ENSMUSP00000020640 | ENSMUSP00000099595 | Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes a [...] | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.999 |
Rack1 | Rpl13 | ENSMUSP00000020640 | ENSMUSP00000000756 | Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes a [...] | 60S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family. | 0.999 |
Rack1 | Rpl19 | ENSMUSP00000020640 | ENSMUSP00000017548 | Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes a [...] | 60S ribosomal protein L19. | 0.999 |
Rack1 | Rpl24 | ENSMUSP00000020640 | ENSMUSP00000023269 | Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes a [...] | 60S ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family. | 0.999 |