node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Caln1 | Fmn1 | ENSMUSP00000083193 | ENSMUSP00000099606 | Calcium-binding protein 8; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning. | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables. | 0.596 |
Ctnna1 | Fmn1 | ENSMUSP00000049007 | ENSMUSP00000099606 | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables. | 0.647 |
Fmn1 | Caln1 | ENSMUSP00000099606 | ENSMUSP00000083193 | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables. | Calcium-binding protein 8; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning. | 0.596 |
Fmn1 | Ctnna1 | ENSMUSP00000099606 | ENSMUSP00000049007 | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables. | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | 0.647 |
Fmn1 | Pfn1 | ENSMUSP00000099606 | ENSMUSP00000018437 | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables. | Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). | 0.740 |
Fmn1 | Pfn2 | ENSMUSP00000099606 | ENSMUSP00000068890 | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables. | Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. | 0.734 |
Fmn1 | Pfn3 | ENSMUSP00000099606 | ENSMUSP00000054053 | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables. | Profilin-3; Binds to actin and affects the structure of the cytoskeleton. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Slightly reduces actin polymerization. May be involved in spermatogenesis. | 0.729 |
Fmn1 | Pfn4 | ENSMUSP00000099606 | ENSMUSP00000136765 | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables. | Profilin-4; Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Does not bind to actin, contrary to other family members (By similarity). | 0.798 |
Fmn1 | Pfn5 | ENSMUSP00000099606 | ENSMUSP00000148168 | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables. | Profilin; Belongs to the profilin family. | 0.730 |
Fmn1 | Prpf40a | ENSMUSP00000099606 | ENSMUSP00000075655 | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables. | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | 0.672 |
Fmn1 | Spire1 | ENSMUSP00000099606 | ENSMUSP00000049336 | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables. | Protein spire homolog 1; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis ; Belongs to the spire family. | 0.928 |
Fmn1 | Spire2 | ENSMUSP00000099606 | ENSMUSP00000010298 | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables. | Protein spire homolog 2; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin [...] | 0.878 |
Pfn1 | Fmn1 | ENSMUSP00000018437 | ENSMUSP00000099606 | Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables. | 0.740 |
Pfn1 | Pfn2 | ENSMUSP00000018437 | ENSMUSP00000068890 | Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). | Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. | 0.934 |
Pfn1 | Pfn3 | ENSMUSP00000018437 | ENSMUSP00000054053 | Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). | Profilin-3; Binds to actin and affects the structure of the cytoskeleton. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Slightly reduces actin polymerization. May be involved in spermatogenesis. | 0.911 |
Pfn1 | Pfn4 | ENSMUSP00000018437 | ENSMUSP00000136765 | Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). | Profilin-4; Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Does not bind to actin, contrary to other family members (By similarity). | 0.936 |
Pfn1 | Prpf40a | ENSMUSP00000018437 | ENSMUSP00000075655 | Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | 0.434 |
Pfn2 | Fmn1 | ENSMUSP00000068890 | ENSMUSP00000099606 | Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables. | 0.734 |
Pfn2 | Pfn1 | ENSMUSP00000068890 | ENSMUSP00000018437 | Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. | Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). | 0.934 |
Pfn2 | Pfn3 | ENSMUSP00000068890 | ENSMUSP00000054053 | Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. | Profilin-3; Binds to actin and affects the structure of the cytoskeleton. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Slightly reduces actin polymerization. May be involved in spermatogenesis. | 0.909 |