node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Armc1 | Mtfr1l | ENSMUSP00000029125 | ENSMUSP00000099609 | Armadillo repeat-containing protein 1. | Mitochondrial fission regulator 1-like. | 0.686 |
Armc10 | Mtfr1l | ENSMUSP00000072669 | ENSMUSP00000099609 | Armadillo repeat-containing protein 10; May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53 (By similarity). | Mitochondrial fission regulator 1-like. | 0.474 |
Armcx3 | Mtfr1l | ENSMUSP00000084097 | ENSMUSP00000099609 | Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the Trak2-kinesin motor complex via its interaction with Miro and Trak2. Mitochondrial distribution and dynamics is regulated through Armcx3 protein degradation, which is promoted by PCK and negatively regulated by Wnt1. Enhances the Sox10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters ; Belongs to the eutherian X-chromosome-specific Armcx family. | Mitochondrial fission regulator 1-like. | 0.463 |
Cstf1 | Mtfr1l | ENSMUSP00000112076 | ENSMUSP00000099609 | Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (By similarity). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity). | Mitochondrial fission regulator 1-like. | 0.664 |
Cstf1 | Vps33a | ENSMUSP00000112076 | ENSMUSP00000031388 | Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (By similarity). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity). | Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosom [...] | 0.404 |
Lamtor3 | Mtfr1l | ENSMUSP00000130811 | ENSMUSP00000099609 | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | Mitochondrial fission regulator 1-like. | 0.497 |
Mavs | Mtfr1l | ENSMUSP00000105828 | ENSMUSP00000099609 | Mitochondrial antiviral-signaling protein; Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF- kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (By similarity). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of def [...] | Mitochondrial fission regulator 1-like. | 0.446 |
Mtfr1l | Armc1 | ENSMUSP00000099609 | ENSMUSP00000029125 | Mitochondrial fission regulator 1-like. | Armadillo repeat-containing protein 1. | 0.686 |
Mtfr1l | Armc10 | ENSMUSP00000099609 | ENSMUSP00000072669 | Mitochondrial fission regulator 1-like. | Armadillo repeat-containing protein 10; May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53 (By similarity). | 0.474 |
Mtfr1l | Armcx3 | ENSMUSP00000099609 | ENSMUSP00000084097 | Mitochondrial fission regulator 1-like. | Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the Trak2-kinesin motor complex via its interaction with Miro and Trak2. Mitochondrial distribution and dynamics is regulated through Armcx3 protein degradation, which is promoted by PCK and negatively regulated by Wnt1. Enhances the Sox10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters ; Belongs to the eutherian X-chromosome-specific Armcx family. | 0.463 |
Mtfr1l | Cstf1 | ENSMUSP00000099609 | ENSMUSP00000112076 | Mitochondrial fission regulator 1-like. | Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (By similarity). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity). | 0.664 |
Mtfr1l | Lamtor3 | ENSMUSP00000099609 | ENSMUSP00000130811 | Mitochondrial fission regulator 1-like. | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | 0.497 |
Mtfr1l | Mavs | ENSMUSP00000099609 | ENSMUSP00000105828 | Mitochondrial fission regulator 1-like. | Mitochondrial antiviral-signaling protein; Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF- kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (By similarity). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of def [...] | 0.446 |
Mtfr1l | Rtf2 | ENSMUSP00000099609 | ENSMUSP00000029005 | Mitochondrial fission regulator 1-like. | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | 0.538 |
Mtfr1l | Slc12a8 | ENSMUSP00000099609 | ENSMUSP00000062337 | Mitochondrial fission regulator 1-like. | Solute carrier family 12 member 8; Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. | 0.556 |
Mtfr1l | Tatdn2 | ENSMUSP00000099609 | ENSMUSP00000145308 | Mitochondrial fission regulator 1-like. | TatD DNase domain-containing 2. | 0.682 |
Mtfr1l | Vps33a | ENSMUSP00000099609 | ENSMUSP00000031388 | Mitochondrial fission regulator 1-like. | Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosom [...] | 0.550 |
Rtf2 | Mtfr1l | ENSMUSP00000029005 | ENSMUSP00000099609 | Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family. | Mitochondrial fission regulator 1-like. | 0.538 |
Slc12a8 | Mtfr1l | ENSMUSP00000062337 | ENSMUSP00000099609 | Solute carrier family 12 member 8; Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. | Mitochondrial fission regulator 1-like. | 0.556 |
Slc12a8 | Tatdn2 | ENSMUSP00000062337 | ENSMUSP00000145308 | Solute carrier family 12 member 8; Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. | TatD DNase domain-containing 2. | 0.523 |