node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cep131 | Fam170b | ENSMUSP00000101834 | ENSMUSP00000100529 | Centrosomal protein of 131 kDa; Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner [...] | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | 0.489 |
Cep131 | Wipf3 | ENSMUSP00000101834 | ENSMUSP00000120240 | Centrosomal protein of 131 kDa; Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner [...] | WAS/WASL-interacting protein family member 3; May be a regulator of cytoskeletal organization (Potential). May have a role in spermatogenesis. | 0.440 |
Fam170b | Cep131 | ENSMUSP00000100529 | ENSMUSP00000101834 | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | Centrosomal protein of 131 kDa; Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner [...] | 0.489 |
Fam170b | Fsip2 | ENSMUSP00000100529 | ENSMUSP00000120314 | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | Fibrous sheath-interacting protein 2; Plays a role in spermatogenesis. | 0.535 |
Fam170b | Gopc | ENSMUSP00000100529 | ENSMUSP00000020008 | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. | 0.499 |
Fam170b | Hfm1 | ENSMUSP00000100529 | ENSMUSP00000108310 | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | Probable ATP-dependent DNA helicase HFM1; Required for crossover formation and complete synapsis of homologous chromosomes during meiosis. | 0.511 |
Fam170b | Iqcf1 | ENSMUSP00000100529 | ENSMUSP00000082195 | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | 0.614 |
Fam170b | Lrrc18 | ENSMUSP00000100529 | ENSMUSP00000041199 | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation. | 0.635 |
Fam170b | Mysm1 | ENSMUSP00000100529 | ENSMUSP00000075269 | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis [...] | 0.565 |
Fam170b | Prss37 | ENSMUSP00000100529 | ENSMUSP00000031967 | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system (By similarity). | 0.563 |
Fam170b | Tnp1 | ENSMUSP00000100529 | ENSMUSP00000027374 | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. The histone H2AB1-H2BC1/TH2B dimer is required for loading of TNP1 onto chromatin. | 0.495 |
Fam170b | Wipf3 | ENSMUSP00000100529 | ENSMUSP00000120240 | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | WAS/WASL-interacting protein family member 3; May be a regulator of cytoskeletal organization (Potential). May have a role in spermatogenesis. | 0.679 |
Fsip2 | Fam170b | ENSMUSP00000120314 | ENSMUSP00000100529 | Fibrous sheath-interacting protein 2; Plays a role in spermatogenesis. | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | 0.535 |
Gopc | Fam170b | ENSMUSP00000020008 | ENSMUSP00000100529 | Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | 0.499 |
Hfm1 | Fam170b | ENSMUSP00000108310 | ENSMUSP00000100529 | Probable ATP-dependent DNA helicase HFM1; Required for crossover formation and complete synapsis of homologous chromosomes during meiosis. | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | 0.511 |
Hfm1 | Prss37 | ENSMUSP00000108310 | ENSMUSP00000031967 | Probable ATP-dependent DNA helicase HFM1; Required for crossover formation and complete synapsis of homologous chromosomes during meiosis. | Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system (By similarity). | 0.416 |
Hfm1 | Wipf3 | ENSMUSP00000108310 | ENSMUSP00000120240 | Probable ATP-dependent DNA helicase HFM1; Required for crossover formation and complete synapsis of homologous chromosomes during meiosis. | WAS/WASL-interacting protein family member 3; May be a regulator of cytoskeletal organization (Potential). May have a role in spermatogenesis. | 0.550 |
Iqcf1 | Fam170b | ENSMUSP00000082195 | ENSMUSP00000100529 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | 0.614 |
Iqcf1 | Prss37 | ENSMUSP00000082195 | ENSMUSP00000031967 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction. | Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system (By similarity). | 0.518 |
Lrrc18 | Fam170b | ENSMUSP00000041199 | ENSMUSP00000100529 | Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation. | Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family. | 0.635 |