node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Brix1 | Bysl | ENSMUSP00000022855 | ENSMUSP00000024783 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | 0.914 |
Brix1 | Gamt | ENSMUSP00000022855 | ENSMUSP00000020359 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development. | 0.766 |
Brix1 | Gtpbp4 | ENSMUSP00000022855 | ENSMUSP00000152412 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 0.997 |
Brix1 | Rpf2 | ENSMUSP00000022855 | ENSMUSP00000138581 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family. | 0.991 |
Bysl | Brix1 | ENSMUSP00000024783 | ENSMUSP00000022855 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | 0.914 |
Bysl | Gamt | ENSMUSP00000024783 | ENSMUSP00000020359 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development. | 0.691 |
Bysl | Gtpbp4 | ENSMUSP00000024783 | ENSMUSP00000152412 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 0.916 |
Bysl | Rpf2 | ENSMUSP00000024783 | ENSMUSP00000138581 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family. | 0.937 |
Ckm | Gamt | ENSMUSP00000146972 | ENSMUSP00000020359 | Creatine kinase M-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development. | 0.698 |
Ckm | Gatm | ENSMUSP00000146972 | ENSMUSP00000028624 | Creatine kinase M-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. | 0.447 |
Ckmt1 | Gamt | ENSMUSP00000000317 | ENSMUSP00000020359 | Creatine kinase U-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development. | 0.698 |
Ckmt1 | Gatm | ENSMUSP00000000317 | ENSMUSP00000028624 | Creatine kinase U-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. | 0.771 |
Ckmt1 | Slc6a8 | ENSMUSP00000000317 | ENSMUSP00000033752 | Creatine kinase U-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. | Sodium- and chloride-dependent creatine transporter 1; Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier. | 0.559 |
Gamt | Brix1 | ENSMUSP00000020359 | ENSMUSP00000022855 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development. | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. | 0.766 |
Gamt | Bysl | ENSMUSP00000020359 | ENSMUSP00000024783 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development. | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family. | 0.691 |
Gamt | Ckm | ENSMUSP00000020359 | ENSMUSP00000146972 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development. | Creatine kinase M-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. | 0.698 |
Gamt | Ckmt1 | ENSMUSP00000020359 | ENSMUSP00000000317 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development. | Creatine kinase U-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. | 0.698 |
Gamt | Gatm | ENSMUSP00000020359 | ENSMUSP00000028624 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development. | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. | 0.956 |
Gamt | Gtpbp4 | ENSMUSP00000020359 | ENSMUSP00000152412 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development. | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. | 0.761 |
Gamt | Mecp2 | ENSMUSP00000020359 | ENSMUSP00000033770 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development. | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC). | 0.843 |