node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cib1 | Coro1a | ENSMUSP00000070901 | ENSMUSP00000101972 | Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] | Coronin-1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. | 0.407 |
Cib1 | Tmc6 | ENSMUSP00000070901 | ENSMUSP00000026659 | Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] | Transmembrane channel-like protein 6; Probable ion channel. | 0.700 |
Cib1 | Tmc8 | ENSMUSP00000070901 | ENSMUSP00000113628 | Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] | Transmembrane channel-like protein 8; Probable ion channel. | 0.542 |
Coro1a | Cib1 | ENSMUSP00000101972 | ENSMUSP00000070901 | Coronin-1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. | Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] | 0.407 |
Coro1a | Tmc8 | ENSMUSP00000101972 | ENSMUSP00000113628 | Coronin-1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. | Transmembrane channel-like protein 8; Probable ion channel. | 0.507 |
Kcng4 | Tmc8 | ENSMUSP00000056552 | ENSMUSP00000113628 | Potassium voltage-gated channel subfamily G member 4; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily. | Transmembrane channel-like protein 8; Probable ion channel. | 0.543 |
Skiv2l | Tmc8 | ENSMUSP00000036265 | ENSMUSP00000113628 | Superkiller viralicidic activity 2-like (S. cerevisiae). | Transmembrane channel-like protein 8; Probable ion channel. | 0.488 |
Slc30a1 | Tmc6 | ENSMUSP00000042410 | ENSMUSP00000026659 | Zinc transporter 1; May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. | Transmembrane channel-like protein 6; Probable ion channel. | 0.932 |
Slc30a1 | Tmc8 | ENSMUSP00000042410 | ENSMUSP00000113628 | Zinc transporter 1; May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. | Transmembrane channel-like protein 8; Probable ion channel. | 0.940 |
Syngr2 | Tha1 | ENSMUSP00000026649 | ENSMUSP00000033230 | Synaptogyrin-2; May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. | L-threonine aldolase. | 0.539 |
Syngr2 | Tmc6 | ENSMUSP00000026649 | ENSMUSP00000026659 | Synaptogyrin-2; May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. | Transmembrane channel-like protein 6; Probable ion channel. | 0.564 |
Syngr2 | Tmc8 | ENSMUSP00000026649 | ENSMUSP00000113628 | Synaptogyrin-2; May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. | Transmembrane channel-like protein 8; Probable ion channel. | 0.688 |
Tfcp2 | Tmc8 | ENSMUSP00000155683 | ENSMUSP00000113628 | Alpha-globin transcription factor CP2; Binds a variety of cellular promoters including fibrinogen, alpha-globin promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter (By similarity). Belongs to the grh/CP2 family. CP2 s [...] | Transmembrane channel-like protein 8; Probable ion channel. | 0.517 |
Tha1 | Syngr2 | ENSMUSP00000033230 | ENSMUSP00000026649 | L-threonine aldolase. | Synaptogyrin-2; May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. | 0.539 |
Tha1 | Tmc8 | ENSMUSP00000033230 | ENSMUSP00000113628 | L-threonine aldolase. | Transmembrane channel-like protein 8; Probable ion channel. | 0.488 |
Tmc6 | Cib1 | ENSMUSP00000026659 | ENSMUSP00000070901 | Transmembrane channel-like protein 6; Probable ion channel. | Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] | 0.700 |
Tmc6 | Slc30a1 | ENSMUSP00000026659 | ENSMUSP00000042410 | Transmembrane channel-like protein 6; Probable ion channel. | Zinc transporter 1; May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. | 0.932 |
Tmc6 | Syngr2 | ENSMUSP00000026659 | ENSMUSP00000026649 | Transmembrane channel-like protein 6; Probable ion channel. | Synaptogyrin-2; May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. | 0.564 |
Tmc6 | Tmc8 | ENSMUSP00000026659 | ENSMUSP00000113628 | Transmembrane channel-like protein 6; Probable ion channel. | Transmembrane channel-like protein 8; Probable ion channel. | 0.529 |
Tmc8 | Cib1 | ENSMUSP00000113628 | ENSMUSP00000070901 | Transmembrane channel-like protein 8; Probable ion channel. | Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] | 0.542 |