STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Clcc1Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel (By similarity). Plays a role in retina development. Belongs to the chloride channel MCLC family. (544 aa)    
Predicted Functional Partners:
Slc25a54
Solute carrier family 25, member 54; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.644
Fam102b
Protein FAM102B; Belongs to the FAM102 family.
      
 0.604
2310009A05Rik
Pigb opposite strand 1.
      
 0.597
Aknad1
AKNA domain-containing 1.
      
 0.554
Wdr47
WD repeat-containing protein 47.
 
    
 0.501
Sec61b
Protein transport protein Sec61 subunit beta; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (By similarity). Required for PKD1/Polycystin-1 biogenesis.
      
 0.493
Gm10320
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.
      
 0.493
1700013F07Rik
Protein C1orf194 homolog; May play an important role for the maintenance of myelin-axon integrity. May affect intracellular Ca(2+) homeostasis (By similarity).
      
 0.489
Cyren
Cell cycle regulator of non-homologous end joining; Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases. Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present. Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homolog [...]
      
 0.473
Tmem167b
Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.
   
  
 0.463
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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