STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cisd3CDGSH iron-sulfur domain-containing protein 3, mitochondrial; Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function. Belongs to the CISD protein family. (137 aa)    
Predicted Functional Partners:
Cisd1
CDGSH iron-sulfur domain-containing protein 1; Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation. May be involved in Fe-S cluster shuttling and/or in redox reactions (By similarity). Belongs to the CISD protein family.
   
  
 0.802
Cisd2
CDGSH iron-sulfur domain-containing protein 2; Regulator of autophagy that contributes to antagonize BECN1- mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (By similarity). Belongs to the CISD protein family. CISD2 subfamily.
      
 0.762
Mrpl17
39S ribosomal protein L17, mitochondrial.
   
 
 0.754
Mrps15
28S ribosomal protein S15, mitochondrial; Belongs to the universal ribosomal protein uS15 family.
   
 
 0.696
Mrpl24
39S ribosomal protein L24, mitochondrial; Belongs to the universal ribosomal protein uL24 family.
   
   0.686
Rpl27a
60S ribosomal protein L27a.
   
 
 0.627
Fam83c
Protein FAM83C; May play a role in MAPK signaling. Belongs to the FAM83 family.
   
  
 0.608
Mllt6
Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6.
 
    
 0.595
Mrps16
28S ribosomal protein S16, mitochondrial; Belongs to the bacterial ribosomal protein bS16 family.
   
   0.582
Mrpl13
39S ribosomal protein L13, mitochondrial; Belongs to the universal ribosomal protein uL13 family.
   
   0.582
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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