node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgap21 | Arhgap23 | ENSMUSP00000122497 | ENSMUSP00000103227 | Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity). | Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | 0.492 |
Arhgap21 | Ccdc85a | ENSMUSP00000122497 | ENSMUSP00000124972 | Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity). | Coiled-coil domain-containing protein 85A; May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family; Belongs to the CCDC85 family. | 0.575 |
Arhgap21 | Ccdc85b | ENSMUSP00000122497 | ENSMUSP00000137537 | Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity). | Coiled-coil domain-containing protein 85B; Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion. Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity); Belongs to the CCDC85 family. | 0.414 |
Arhgap21 | Ccdc85c | ENSMUSP00000122497 | ENSMUSP00000152421 | Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity). | Coiled-coil domain-containing protein 85C; May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). May play an important role in cortical development, especially in the maintenance of radial glia. | 0.597 |
Arhgap21 | Prickle1 | ENSMUSP00000122497 | ENSMUSP00000104878 | Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity). | Prickle-like protein 1; Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure (By similarity). Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor (By similarity). | 0.796 |
Arhgap21 | Rhoa | ENSMUSP00000122497 | ENSMUSP00000007959 | Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity). | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (By similarity). [...] | 0.636 |
Arhgap21 | Srcin1 | ENSMUSP00000122497 | ENSMUSP00000103222 | Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity). | SRC kinase signaling inhibitor 1; Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance (By similarity). | 0.428 |
Arhgap23 | Arhgap21 | ENSMUSP00000103227 | ENSMUSP00000122497 | Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity). | 0.492 |
Arhgap23 | Ccdc51 | ENSMUSP00000103227 | ENSMUSP00000026735 | Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Mitochondrial potassium channel; Mitochondrial potassium channel located in the mitochondrial inner membrane. Together with ABCB8/MITOSUR, forms a protein complex localized in the mitochondria that mediates ATP- dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel). May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume. | 0.675 |
Arhgap23 | Ccdc85a | ENSMUSP00000103227 | ENSMUSP00000124972 | Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Coiled-coil domain-containing protein 85A; May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family; Belongs to the CCDC85 family. | 0.695 |
Arhgap23 | Ccdc85b | ENSMUSP00000103227 | ENSMUSP00000137537 | Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Coiled-coil domain-containing protein 85B; Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion. Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity); Belongs to the CCDC85 family. | 0.520 |
Arhgap23 | Ccdc85c | ENSMUSP00000103227 | ENSMUSP00000152421 | Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Coiled-coil domain-containing protein 85C; May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). May play an important role in cortical development, especially in the maintenance of radial glia. | 0.703 |
Arhgap23 | Prickle1 | ENSMUSP00000103227 | ENSMUSP00000104878 | Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Prickle-like protein 1; Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure (By similarity). Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor (By similarity). | 0.569 |
Arhgap23 | Rapgefl1 | ENSMUSP00000103227 | ENSMUSP00000103103 | Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF). | 0.549 |
Arhgap23 | Rhoa | ENSMUSP00000103227 | ENSMUSP00000007959 | Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (By similarity). [...] | 0.521 |
Arhgap23 | Srcin1 | ENSMUSP00000103227 | ENSMUSP00000103222 | Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | SRC kinase signaling inhibitor 1; Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance (By similarity). | 0.653 |
Arhgap23 | Zfp541 | ENSMUSP00000103227 | ENSMUSP00000147475 | Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis. | 0.675 |
Ccdc51 | Arhgap23 | ENSMUSP00000026735 | ENSMUSP00000103227 | Mitochondrial potassium channel; Mitochondrial potassium channel located in the mitochondrial inner membrane. Together with ABCB8/MITOSUR, forms a protein complex localized in the mitochondria that mediates ATP- dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel). May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume. | Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | 0.675 |
Ccdc51 | Zfp541 | ENSMUSP00000026735 | ENSMUSP00000147475 | Mitochondrial potassium channel; Mitochondrial potassium channel located in the mitochondrial inner membrane. Together with ABCB8/MITOSUR, forms a protein complex localized in the mitochondria that mediates ATP- dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel). May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume. | Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis. | 0.677 |
Ccdc85a | Arhgap21 | ENSMUSP00000124972 | ENSMUSP00000122497 | Coiled-coil domain-containing protein 85A; May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family; Belongs to the CCDC85 family. | Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity). | 0.575 |