node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ankrd17 | Asxl2 | ENSMUSP00000014421 | ENSMUSP00000117384 | Ankyrin repeat domain-containing protein 17; Could play pivotal roles in cell cycle and DNA regulation. Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways. Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too. Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system. | Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated [...] | 0.481 |
Ankrd17 | Tmem245 | ENSMUSP00000014421 | ENSMUSP00000103234 | Ankyrin repeat domain-containing protein 17; Could play pivotal roles in cell cycle and DNA regulation. Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways. Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too. Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system. | Transmembrane protein 245. | 0.672 |
Ankrd17 | Usp34 | ENSMUSP00000014421 | ENSMUSP00000137430 | Ankyrin repeat domain-containing protein 17; Could play pivotal roles in cell cycle and DNA regulation. Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways. Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too. Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system. | Ubiquitin carboxyl-terminal hydrolase 34; Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precurs [...] | 0.890 |
Asxl2 | Ankrd17 | ENSMUSP00000117384 | ENSMUSP00000014421 | Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated [...] | Ankyrin repeat domain-containing protein 17; Could play pivotal roles in cell cycle and DNA regulation. Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways. Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too. Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system. | 0.481 |
Asxl2 | Tmem245 | ENSMUSP00000117384 | ENSMUSP00000103234 | Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated [...] | Transmembrane protein 245. | 0.495 |
Asxl2 | Ubn2 | ENSMUSP00000117384 | ENSMUSP00000124043 | Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated [...] | Ubinuclein-2. | 0.510 |
C77080 | Tmem245 | ENSMUSP00000062395 | ENSMUSP00000103234 | Uncharacterized protein KIAA1522. | Transmembrane protein 245. | 0.485 |
Ctnnal1 | Tmem245 | ENSMUSP00000036487 | ENSMUSP00000103234 | Alpha-catulin; May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1). | Transmembrane protein 245. | 0.515 |
Msantd3 | Tmem245 | ENSMUSP00000103332 | ENSMUSP00000103234 | Myb/SANT-like DNA-binding domain-containing protein 3; Belongs to the MSANTD3 family. | Transmembrane protein 245. | 0.501 |
Sra1 | Tmem245 | ENSMUSP00000133360 | ENSMUSP00000103234 | Steroid receptor RNA activator 1; Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N- terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis (By similarity). Belongs to the SRA1 family. | Transmembrane protein 245. | 0.489 |
Tmem184a | Tmem245 | ENSMUSP00000035399 | ENSMUSP00000103234 | Transmembrane protein 184A; Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells. Belongs to the TMEM184 family. | Transmembrane protein 245. | 0.594 |
Tmem245 | Ankrd17 | ENSMUSP00000103234 | ENSMUSP00000014421 | Transmembrane protein 245. | Ankyrin repeat domain-containing protein 17; Could play pivotal roles in cell cycle and DNA regulation. Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways. Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too. Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system. | 0.672 |
Tmem245 | Asxl2 | ENSMUSP00000103234 | ENSMUSP00000117384 | Transmembrane protein 245. | Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated [...] | 0.495 |
Tmem245 | C77080 | ENSMUSP00000103234 | ENSMUSP00000062395 | Transmembrane protein 245. | Uncharacterized protein KIAA1522. | 0.485 |
Tmem245 | Ctnnal1 | ENSMUSP00000103234 | ENSMUSP00000036487 | Transmembrane protein 245. | Alpha-catulin; May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1). | 0.515 |
Tmem245 | Msantd3 | ENSMUSP00000103234 | ENSMUSP00000103332 | Transmembrane protein 245. | Myb/SANT-like DNA-binding domain-containing protein 3; Belongs to the MSANTD3 family. | 0.501 |
Tmem245 | Sra1 | ENSMUSP00000103234 | ENSMUSP00000133360 | Transmembrane protein 245. | Steroid receptor RNA activator 1; Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N- terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis (By similarity). Belongs to the SRA1 family. | 0.489 |
Tmem245 | Tmem184a | ENSMUSP00000103234 | ENSMUSP00000035399 | Transmembrane protein 245. | Transmembrane protein 184A; Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells. Belongs to the TMEM184 family. | 0.594 |
Tmem245 | Ubn2 | ENSMUSP00000103234 | ENSMUSP00000124043 | Transmembrane protein 245. | Ubinuclein-2. | 0.668 |
Tmem245 | Usp34 | ENSMUSP00000103234 | ENSMUSP00000137430 | Transmembrane protein 245. | Ubiquitin carboxyl-terminal hydrolase 34; Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precurs [...] | 0.796 |