node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B3gnt2 | Pkd1l2 | ENSMUSP00000060247 | ENSMUSP00000095977 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2; Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Probably constitutes the main polylactosamine synthase ; Belongs to the glycosyltransferase 31 family. | Polycystic kidney disease protein 1-like 2; May function as an ion-channel regulator. May function as a G-protein-coupled receptor (By similarity). | 0.452 |
Bco1 | Gcsh | ENSMUSP00000034308 | ENSMUSP00000037131 | Beta,beta-carotene 15,15'-dioxygenase; Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism; Belongs to the carotenoid oxygenase family. | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST) (By similarity). Belongs to the GcvH family. | 0.422 |
Bco1 | Pkd1l2 | ENSMUSP00000034308 | ENSMUSP00000095977 | Beta,beta-carotene 15,15'-dioxygenase; Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism; Belongs to the carotenoid oxygenase family. | Polycystic kidney disease protein 1-like 2; May function as an ion-channel regulator. May function as a G-protein-coupled receptor (By similarity). | 0.646 |
Bco1 | Rbp4 | ENSMUSP00000034308 | ENSMUSP00000025951 | Beta,beta-carotene 15,15'-dioxygenase; Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism; Belongs to the carotenoid oxygenase family. | Retinol-binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. | 0.527 |
Fggy | Pkd1l2 | ENSMUSP00000078216 | ENSMUSP00000095977 | FGGY carbohydrate kinase domain-containing protein. | Polycystic kidney disease protein 1-like 2; May function as an ion-channel regulator. May function as a G-protein-coupled receptor (By similarity). | 0.459 |
Gcsh | Bco1 | ENSMUSP00000037131 | ENSMUSP00000034308 | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST) (By similarity). Belongs to the GcvH family. | Beta,beta-carotene 15,15'-dioxygenase; Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism; Belongs to the carotenoid oxygenase family. | 0.422 |
Gcsh | Pkd1l2 | ENSMUSP00000037131 | ENSMUSP00000095977 | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST) (By similarity). Belongs to the GcvH family. | Polycystic kidney disease protein 1-like 2; May function as an ion-channel regulator. May function as a G-protein-coupled receptor (By similarity). | 0.580 |
Gna12 | Gnai2 | ENSMUSP00000000153 | ENSMUSP00000057543 | Guanine nucleotide-binding protein subunit alpha-12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (By similarity). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (By similarity). Promotes tumor cell invasion and metastasis by activatin [...] | Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division. | 0.615 |
Gna12 | Gnas | ENSMUSP00000000153 | ENSMUSP00000140174 | Guanine nucleotide-binding protein subunit alpha-12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (By similarity). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (By similarity). Promotes tumor cell invasion and metastasis by activatin [...] | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. | 0.749 |
Gna12 | Pkd1l2 | ENSMUSP00000000153 | ENSMUSP00000095977 | Guanine nucleotide-binding protein subunit alpha-12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (By similarity). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (By similarity). Promotes tumor cell invasion and metastasis by activatin [...] | Polycystic kidney disease protein 1-like 2; May function as an ion-channel regulator. May function as a G-protein-coupled receptor (By similarity). | 0.478 |
Gnai2 | Gna12 | ENSMUSP00000057543 | ENSMUSP00000000153 | Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division. | Guanine nucleotide-binding protein subunit alpha-12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (By similarity). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (By similarity). Promotes tumor cell invasion and metastasis by activatin [...] | 0.615 |
Gnai2 | Gnas | ENSMUSP00000057543 | ENSMUSP00000140174 | Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division. | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. | 0.649 |
Gnai2 | Pkd1l2 | ENSMUSP00000057543 | ENSMUSP00000095977 | Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division. | Polycystic kidney disease protein 1-like 2; May function as an ion-channel regulator. May function as a G-protein-coupled receptor (By similarity). | 0.495 |
Gnas | Gna12 | ENSMUSP00000140174 | ENSMUSP00000000153 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. | Guanine nucleotide-binding protein subunit alpha-12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (By similarity). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (By similarity). Promotes tumor cell invasion and metastasis by activatin [...] | 0.749 |
Gnas | Gnai2 | ENSMUSP00000140174 | ENSMUSP00000057543 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. | Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division. | 0.649 |
Gnas | Pkd1l2 | ENSMUSP00000140174 | ENSMUSP00000095977 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. | Polycystic kidney disease protein 1-like 2; May function as an ion-channel regulator. May function as a G-protein-coupled receptor (By similarity). | 0.439 |
Pdzk1ip1 | Pkd1l2 | ENSMUSP00000128118 | ENSMUSP00000095977 | PDZK1-interacting protein 1. | Polycystic kidney disease protein 1-like 2; May function as an ion-channel regulator. May function as a G-protein-coupled receptor (By similarity). | 0.556 |
Pkd1l2 | B3gnt2 | ENSMUSP00000095977 | ENSMUSP00000060247 | Polycystic kidney disease protein 1-like 2; May function as an ion-channel regulator. May function as a G-protein-coupled receptor (By similarity). | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2; Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Probably constitutes the main polylactosamine synthase ; Belongs to the glycosyltransferase 31 family. | 0.452 |
Pkd1l2 | Bco1 | ENSMUSP00000095977 | ENSMUSP00000034308 | Polycystic kidney disease protein 1-like 2; May function as an ion-channel regulator. May function as a G-protein-coupled receptor (By similarity). | Beta,beta-carotene 15,15'-dioxygenase; Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism; Belongs to the carotenoid oxygenase family. | 0.646 |
Pkd1l2 | Fggy | ENSMUSP00000095977 | ENSMUSP00000078216 | Polycystic kidney disease protein 1-like 2; May function as an ion-channel regulator. May function as a G-protein-coupled receptor (By similarity). | FGGY carbohydrate kinase domain-containing protein. | 0.459 |