STRINGSTRING
Tshz2 protein (mouse) - STRING interaction network
"Tshz2" - Teashirt zinc finger family member 2 in Mus musculus
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Tshz2Teashirt zinc finger family member 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential) (1030 aa)    
Predicted Functional Partners:
Meis1
Meis homeobox 1; Acts as a transcriptional regulator of PAX6. Also acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias (465 aa)
     
 
  0.608
Meis2
Meis homeobox 2; Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in [...] (477 aa)
     
 
  0.608
Meis3
Meis homeobox 3; Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1 (378 aa)
     
 
  0.608
Lrrc42
Leucine rich repeat containing 42 (421 aa)
           
  0.481
ENSMUSG00000042579
RIKEN cDNA 4632404H12 gene (128 aa)
           
  0.461
Eya2
Eyes absent 2 homolog (Drosophila); Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed-10490620, PubMed-17098221). Tyrosine phosphatase that dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may con [...] (532 aa)
       
 
  0.428
Macc1
Metastasis associated in colon cancer 1 (851 aa)
           
  0.408
Zfp64
Zinc finger protein 64 (676 aa)
       
 
  0.408
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mice, mouse, nude mice, transgenic mice
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